Kelly Turner
Turmeric ndi muzu wachikasu wochokera ku Asia womwe umapatsa zonunkhira zodziwika bwino za curry mtundu wake wachikasu. Komabe, turmeric ndi zambiri kuposa zonunkhira. Chifukwa chakhala chida chofunikira kwambiri ku Ayurveda, luso la machiritso lachi India lazaka chikwi. Pakadali pano, kafukufuku wosiyanasiyana apeza kuti curcumin, chomwe chimagwira ntchito mu turmeric, chimagwiranso ntchito m'mankhwala ena.
Kodi mungatenge turmeric ndi curcumin m'malo mwa mankhwala?
Mukagula turmeric, ndi bwino kugula zambiri. Chifukwa ufa wachikasu wakuya ndiwothandiza pazovuta zambiri - zonse zochiritsira komanso zodzitetezera - kuti mutha kuziphatikiza muzakudya zanu zatsiku ndi tsiku. Kwa madandaulo enieni, komabe, ndizomveka kutenga curcumin - chinthu chokhazikika chokhazikika kuchokera ku turmeric - mu mawonekedwe a capsule. M'nkhani zambiri zosiyanasiyana, tanena za maphunziro omwe alipo kale pa ubwino wochititsa chidwi wa thanzi la turmeric ndi chogwiritsira ntchito, curcumin.
Ndi zotsatira zabwino zonse za ufa wachikasu, munthu mwachibadwa amadabwa ngati wina angamwe m'malo mwa mankhwala ena. Chifukwa ngakhale kuti mankhwala osokoneza bongo nthawi zambiri amakhala ndi zotsatirapo zambiri, zotsatira za curcumin ndizochepa kwambiri, ngati pali zotsatira zosafunika konse. Nthawi zambiri zimachitika kuti zotsatira zoyipa za mankhwala a curcumin zimasinthidwa.
Choncho ngakhale kuti mankhwala ambiri amatha kuwononga chiwindi, curcumin imakhala ndi chitetezo cha chiwindi, pamene mankhwala osokoneza bongo amafooketsa chitetezo cha mthupi, curcumin imakhala ndi mphamvu yowonjezera chitetezo cha mthupi, ndipo pamene mankhwala ena amawonjezera shuga wa magazi, curcumin imathandiza kuwongolera.
Curcumin m'malo mwa antidepressants?
Fluoxetine ndi mankhwala otchuka padziko lonse lapansi omwe amagwiritsidwa ntchito pochiza matenda osokoneza bongo, bulimia, ndi kudya kwambiri. Zotsatira zake zimakhala zovuta kwambiri kotero kuti odwala nthawi zambiri amasiya kumwa mankhwalawa, mwachitsanzo B. mu vuto la kugona, nkhawa, mantha, nseru, kutopa, zotupa pakhungu, kapena maganizo ofuna kudzipha.
Curcumin imakhalanso ndi antidepressant zotsatira. Mu 2014, ofufuza aku India adachita kafukufuku momwe adafanizira zotsatira za curcumin ndi zotsatira za fluoxetine pakukhumudwa. Odwala 60 omwe adapezeka kuti ali ndi vuto la kukhumudwa adalandira 20 mg ya fluoxetine, 1000 mg ya curcumin, kapena kuphatikiza zonse ziwiri tsiku lililonse kwa milungu isanu ndi umodzi. Odwala omwe adamwa mankhwala onse awiriwa adapeza bwino. Chomwe chinali chosangalatsa, komabe, chinali chakuti omwe adangotenga curcumin okhawo adachita chimodzimodzi ndi odwala omwe adangotenga fluoxetine. Pankhani ya kukhumudwa, curcumin imathanso kuphatikizidwa muzamankhwala.
Curcumin m'malo mwa ochepetsa magazi?
Mankhwala osiyanasiyana amaperekedwa kuti achepetse magazi. Komabe, kafukufuku wina woyamba akuwonetsa kuti turmeric kapena curcumin imakhalanso ndi anticoagulant effect. Popeza curcumin amaonedwa kuti ndi yotetezeka pamiyeso yofikira 8 g (malinga ndi ndemanga yochokera ku 2019), zotsatira zake (kutuluka magazi mkati) zomwe zimadziwika ndi anticoagulants wamba siziyenera kuyembekezera ndi curcumin.
Tsoka ilo, mlingo wa turmeric pazifukwa izi mwa anthu sudziwika, kotero munthu sangangosinthana ndi mankhwala ochepetsa magazi a turmeric kapena curcumin. Komabe, ngati njira yodzitetezera, mutha kugwiritsa ntchito nthawi zonse kukonzekera kwa turmeric kapena curcumin kuti muwongolere magazi.
Curcumin m'malo mwa Metformin?
Curcumin ikhoza kukhala yothandiza pa matenda a shuga kapena oyambitsa matenda a shuga. Mu kafukufuku wa 2009, kafukufuku wama cell adawonetsa kuti curcumin ili ndi nthawi 400 mpaka 100,000 kuthekera kwa metformin pamachitidwe ena. Metformin ndi mankhwala omwe nthawi zambiri amaperekedwa kwa odwala matenda ashuga. Imalepheretsa kuyamwa kwa shuga m'matumbo komanso kupangika kwa glucose watsopano m'chiwindi. Curcumin amanenedwa kuti amatha kuchepetsa shuga m'magazi mofanana kwambiri. Zimadziwikanso kuti curcumin imatha kusintha zovuta zanthawi yayitali za matenda ashuga.
Ndemanga ya 2013 idawonetsanso kuti curcumin ikhoza kuphatikizidwa muzamankhwala a shuga chifukwa imathandizira kuwongolera kuchuluka kwa shuga m'magazi.
Ndipo mu 2012, zidapezeka kuti kutenga 1500 mg wa curcumin patsiku (kwa miyezi 9) kumachepetsa chiopsezo chokhala ndi matenda a shuga a prediabetes kukhala shuga weniweni. Onani ulalo woyamba mugawoli kuti mudziwe zambiri za curcumin mu shuga.
Curcumin m'malo mwa ma statins?
Ma Statins (mankhwala ochepetsa mafuta m'thupi) nthawi zambiri amaperekedwa kuti achepetse cholesterol. Izi siziyenera kutsitsa mlingo wa kolesterolini komanso kukhala ndi chiyambukiro chabwino pa mkhalidwe wa makoma a mtsempha wa mwazi motero zimachepetsa chiopsezo cha arteriosclerosis kapena kuletsa ma depositi ochuluka kupanga pa makoma a mitsempha ya mwazi.
Makoma onse a mitsempha yamagazi amatchedwa vascular endothelium. Ngati mitsempha ya endothelium ili yathanzi, imalepheretsa mapulateleti a magazi kuti asagwedezeke, imatulutsa zinthu zotsutsa-kutupa, imatambasula ziwiya, ndikumenyana ndi kupsinjika kwa okosijeni komwe kukubwera. Mwachidule, mitsempha yamagazi imatha kukhala yathanzi. Komabe, pakawonongeka kwa mitsempha ya endothelium (yomwe nthawi zambiri imakhala ndi matenda a shuga), ndiye kuti mbali yaikulu ya chitetezo cha endothelium chomwe chimafotokozedwa sichikusowa, ndipo zochitika zamtima (monga matenda a mtima) zikhoza kuchitika.
Komabe, popeza ma statins amatha kuthandizira kukula kwa matenda ashuga, sizothandiza nthawi zonse kupereka ma statins kwa odwala matenda ashuga mwa anthu onse. Zotsatira zina za ma statins ndi kufooka kwa minofu ndi kupweteka, vuto la maso, kuwonongeka kwa chiwindi ndi impso. Njira ina m'malo mwa ma statins ingakhale lingaliro labwino, makamaka kwa odwala matenda ashuga.
Popeza curcumin imakhala ndi zotsatira zabwino pamagulu a shuga a magazi komanso imakhala ndi anti-inflammatory effect, yomwe imatha kuteteza mitsempha ya magazi, mu 2008 72 mitundu ya 2 ya matenda a shuga inayesedwa kuti awone ngati curcumin ingavomerezedwe m'malo mwa statins. Ophunzirawo adatenga chowonjezera chokhazikika cha curcumin (150 mg aliyense), statin atorvastatin (10 mg kamodzi patsiku), kapena placebo kawiri tsiku lililonse kwa milungu isanu ndi itatu.
Kumayambiriro kwa phunzirolo, matenda a mitsempha ya odwala onse anali osauka mofanana. Pambuyo pa masabata asanu ndi atatu, komabe, zinthu zinasintha kwambiri - osati m'gulu la placebo. Komabe, m'magulu a statin ndi curcumin, zizindikiro zowonongeka zinachepa ndipo milingo ya malondialdehyde (biomarker of oxidative stress) inachepanso.
Malinga ndi ochita kafukufuku, zotsatira za curcumin zinali zofanana ndi zomwe zimagwiritsidwa ntchito (atorvastatin). Atorvastatin ndi amodzi mwa ma statins amphamvu kwambiri omwe amapezeka. Chonde dziwani kuti izi sizokhudza kutsitsa kwa cholesterol, komwe munthu angatenge curcumin m'malo mwa ma statins, koma "kokha" pazachitetezo choteteza mitsempha.
Komabe, kafukufuku adawonekera mu Nutrition Journal mu 2017, yomwe idati anthu omwe adalandira turmeric ndi curcumin adakumana ndi chitetezo chachilengedwe chamtima, m'kupita kwanthawi komwe ma LDL cholesterol ndi triglycerides amatha kuchepetsedwa. Komabe, sizinadziwikebe kuti ndi mlingo wanji, mtundu wa kukonzekera, komanso kuchuluka kwa makonzedwe omwe akufunika kuti achepetse lipids m'magazi. Ufa woyera wa turmeric mwina siwokwanira ndipo wina amayenera kukonzekera ndi kuchuluka kwa bioavailability. M'maphunziro apitalo, 900 mpaka 1000 mg wa curcumin adayikidwa.
Mutha kugwiritsanso ntchito curcumin ngati mukufuna / mukufuna kumwa ma statins koma osawalekerera bwino ndikumva kupweteka kwa minofu kuchokera kwa iwo. Ndemanga ya 2017 idalemba mayeso awiri azachipatala omwe adawonetsa kuti curcumin imatha kuthetsa ululu wokhudzana ndi minofu ya statin m'masiku 4 mpaka 5. Mu kafukufuku wina, odwala adatenga 200 mg wa curcumin kawiri pa tsiku, ndipo winayo, adatenga 2,500 mg wa curcumin kawiri pa tsiku.
Chinthu chinanso chomwe chimakutetezani ku zovuta za minofu (myopathies) yoyambitsidwa ndi ma statins ndi coenzyme Q10.
Chidziwitso: Pakuwona kwathunthu, kukhala ndi cholesterol yathanzi kapena mitsempha yamagazi yathanzi kumafunikira njira zingapo nthawi imodzi. Choncho ndi bwino kuti musadalire mankhwala amodzi - ziribe kanthu momwe chilengedwe chimakhalira komanso momwe chikuwonekera, kuphatikizapo curcumin yekha.
Curcumin m'malo mwa cortisone?
Zotsutsana ndi kutupa ndizodziwika bwino kwambiri za turmeric ndi curcumin. Njira yogwirira ntchito imanenedwa kukhala yofanana ndi ya glucocorticoids (cortisone). Cortisone amaonedwa kuti ndi mankhwala amphamvu odana ndi kutupa omwe amagwiritsidwa ntchito pazovuta zambiri (monga chifuwa, chifuwa cha mphumu, kubwereranso m'matenda a autoimmune, mwachitsanzo mu MS, Crohn's disease, etc.), komanso kwamuyaya mu matenda otupa, mwachitsanzo B. mu mphumu, COPD, M. Basedow, ndi matenda ena a nyamakazi.
Corticosteroids ikhoza kukhala ndi zotsatira zosasangalatsa, makamaka pogwiritsa ntchito nthawi yayitali. Kuwonjezera pa kusunga madzi, nkhope ya mwezi wathunthu, chilakolako champhamvu, motero kunenepa kwambiri, cortisone ingachepetse chitetezo cha thupi, kuonjezera chiopsezo cha matenda ndi kuonjezera mlingo wa shuga m'magazi, zomwe zimaphatikizapo chiopsezo china cha matenda a shuga.
Cortisone imawononganso thanzi la mafupa - m'njira zingapo: Cortisone imachepetsa mphamvu ya vitamini D, imalepheretsa kuyamwa kwa calcium m'matumbo, imathandizira kutuluka kwa calcium ndi mkodzo, imatchinga osteoblasts (ma cell omanga mafupa), ndipo imafooketsa mafupa. minofu (mafupa amafunika minofu yamphamvu).
Zotsatira zabwino za curcumin
Kodi tsopano mungatenge curcumin m'malo mwa cortisone? Chifukwa curcumin imayang'anira kuchuluka kwa shuga m'magazi, imalimbitsa chitetezo cha mthupi, komanso imakhala ndi zotsatira zabwino pamafupa. Pankhani ya thanzi la mafupa, pali phunziro lochititsa chidwi loyang'aniridwa lachipatala kuyambira June 2018. Zinapezeka mwa odwala 100 kuti kayendetsedwe ka tsiku ndi tsiku kwa 110 mg wa curcumin pa kilogalamu ya kulemera kwa thupi pa miyezi 6 - poyerekeza ndi gulu la placebo - akhoza kulepheretsa kukula kwa osteoporosis. Kuchulukana kwa mafupa kunachepa m'gulu la placebo panthawi ya phunziroli, koma kuchuluka kwa gulu la curcumin. (Zindikirani: Mlingo wa curcumin ndi wokwera kwambiri ndipo uyenera kukhala ndi nyongolotsi pang'onopang'ono komanso mutakambirana ndi dokotala!)
Zotsatira zoyipa za cortisone siziyenera kuyembekezeredwa kuchokera ku curcumin. M'malo mwake. Curcumin ili ndi zotsatira zabwino kwambiri. Koma kodi anti-inflammatory effect ndiyokwanira?
Anti-kutupa zotsatira za curcumin ndi cortisone
Mu 2016, akatswiri awiri a zamankhwala, Pulofesa Alexandra K. Kilmer ndi Jessica Hoppstädter ochokera ku yunivesite ya Saarland anafufuza za anti-inflammatory properties za curcumin. Mankhwala a turmeric amakhudza - monga cortisone - mapuloteni enieni (GILZ), omwe amathandiza kwambiri kutupa m'thupi la munthu. GILZ imalepheretsa kutupa, kotero imatsimikizira kuti mwachitsanzo B. pambuyo pa matenda, chithandizo choyambirira chothandizira sichikhala chokhalitsa. Cortisone imagwira ntchito motsutsana ndi kutupa kosatha powonjezera milingo ya GILZ m'thupi.
Curcumin imathanso kulimbikitsa mapangidwe a GILZ. Komabe, pamene cortisone imayambitsa njira zina m'thupi zomwe zimayambitsa zotsatira za cortisone, izi sizili choncho ndi curcumin. Komabe, kuyesaku kunachitika mu chubu choyesera, kotero sizikudziwika kuti curcumin angagwiritsidwe ntchito m'malo mwa cortisone.
Komabe, kuchokera ku maphunziro osiyanasiyana (in vitro, nyama, ndi maphunziro azachipatala) zimadziwika kuti anti-inflammatory effect imaperekedwa pa mlingo wa 1125 mpaka 2500 mg. Kutengera ndi zizindikiro zapayekha, zili pano - monga momwe zimakhalira nthawi zambiri ndi mankhwala a naturopathic - kudziyesa nokha mlingo womwe mukufunikira kuti mupumule. Ndizotheka kuti kukonzekera kwabwino kwa curcumin sikokwanira ku matenda otupa kwambiri chifukwa cha kufooka kwawo kwachilengedwe, ndipo panonso kukonzekera kowonjezereka kwa bioavailable kuyenera kugwiritsidwa ntchito (mwachitsanzo, Curcumin Forte kuchokera ku chilengedwe chothandiza ndi nthawi 185 ya bioavailability).
Chifukwa chiyani palibe maphunziro aliwonse pamutuwu
Tsopano popeza curcumin ikuwonetsa malonjezano ochuluka pankhani yoletsa kutupa kosatha, kodi tingayembekezere maphunziro ochulukirapo pamutuwu? Pulofesa Kilmer amapereka chiyembekezo chochepa ndipo akufotokoza mu Deutsche Apotheker Zeitung (DAZ) kuti: “Opanga zinthu zogwira ntchito ayenera kupereka maphunziro akuluakulu azachipatala kuti avomerezedwe ngati mankhwala. Chifukwa cha kusowa kwa chitetezo cha patent, izi sizingapezeke ndalama. ” Ichi ndi chifukwa chake kafukufuku wa zakudya zambiri zothandiza kwambiri nthawi zambiri zimakhala zofooka. Mkhalidwe wofooka wophunzirira umaperekedwa ndi malo ogula ngati mkangano chifukwa chake mankhwalawa sayenera kugwiritsidwa ntchito.
Turmeric ndi curcumin m'malo mwa mankhwala?
Inde, simukungotenga makapisozi a turmeric kapena curcumin m'malo mwa mankhwala anu pakali pano. Komabe, ngati simunamwebe mankhwala aliwonse, koma dokotala wanu wakupatsani kale zizindikiro zoyamba mwachitsanzo, ngati muli ndi matenda a shuga kapena matenda a mtima, lankhulani naye za turmeric ndi curcumin. Ndizotheka kuti simuyenera kumwa mankhwala aliwonse, koma mutha kuyamba kumwa makapisozi a curcumin kwa milungu ingapo.
Ngati mukumwa kale mankhwala, mutha kulankhulanso ndi dokotala kapena naturopath ngati mutha kumwa turmeric / curcumin nthawi yomweyo. Izi nthawi zambiri sizimangowonjezera zotsatira za mankhwalawa koma, monga momwe mwawerengera pamwambapa, nthawi zambiri zimachepetsanso zotsatirapo. Komanso, pakapita nthawi, mukhoza kusiya kumwa mankhwala, kapena kuchepetsa mlingo. Inde, muyenera kuganiziranso za zakudya zopatsa thanzi, kugona mokwanira, kuchepetsa nkhawa, komanso kuchita masewera olimbitsa thupi ambiri!
