Gluten Mafuta a Hashimoto's Thyroiditis

Matenda a autoimmune amasiyabe madokotala ambiri mumdima komanso odwala omwe ali ndi mafunso ambiri. Chimodzi mwazinthu zomwe zimakhudzidwa kwambiri ndi chitetezo chamthupi chimabweretsa kutupa kosatha kwa chithokomiro cha Hashimoto's thyroiditis.

Kugwirizana pakati pa Hashimoto ndi gluten

Anthu omwe ali ndi vuto la autoimmune ali ndi chinthu chimodzi chofanana: mavuto am'matumbo. Chifukwa 80 peresenti ya chitetezo cha mthupi chimakhala m'matumbo, makamaka m'matumbo aang'ono. Matenda a autoimmune akamakula kwambiri, amatchulidwanso kuti leaky gut syndrome - khoma lamatumbo lomwe limalola kuti tinthu tating'ono ta chakudya tidutse popanda cholepheretsa m'mimba kulowa m'magazi.

Madokotala Datis Kharrazian ndi Chris Kresser ochokera ku USA tsopano akujambula mgwirizano wodalirika pakati pa kusalolera kwa gilateni ndi kutupa kwa chithokomiro cha autoimmune cha Hashimoto's thyroiditis.

Pochita zimenezi, amakopa chithandizo chamankhwala ku chitetezo cha m’thupi m’malo mongopereka chithandizo cha chithokomiro m’malo mwa mahomoni.

Autoimmunity - Pamene thupi limadziukira lokha

Tisanatembenukire ku kulumikizana pakati pa kutupa kwa chithokomiro cha Hashimoto's thyroiditis ndi kusalolera kwa gluteni, tiyeni tifotokoze bwino chomwe autoimmunity kwenikweni ndi.

Autoimmunity ndi njira yomwe chitetezo chathu cha mthupi chimaukira minofu yokhazikika, mwachitsanzo, chamoyo chathu. Nthawi zambiri, ntchito ya chitetezo cha mthupi ndi kutiteteza ku matenda a bakiteriya, mavairasi, ndi parasitic.

Kuti tichite zimenezi, chitetezo cha m’thupi chimapanga ma antibodies amene amaunjikana m’magazi ndi kuchitapo kanthu motsutsana ndi oukirawo asanatidwalitse.

Komano, autoimmunity, imatha kuyerekezedwa bwino ndi momwe zimakhalira pamene minofu yakunja imakanidwa ndi thupi pambuyo poika chiwalo. Minofu ya munthu aliyense imakhala ndi mamolekyu omwe chitetezo cha mthupi chimazindikira kuti ndi okhazikika ndipo chimawasiyanitsa ndi maselo akunja.

Ngati chiwalo choperekedwa sichikugwirizana kwambiri ndi minofu ya wolandirayo, chitetezo chamthupi chimalowerera ndikuwononga chiwalo chakunja.

Ngati autoimmunity ilipo, njira zofanana zimachitika m'thupi monga kukana kwa chiwalo. Minofu ya thupi lomwe silidziwika ndi chitetezo chamthupi ndipo m'malo mwake - ngati kuti ndi minofu yachilendo - imawukiridwa ndikuwonongedwa pang'onopang'ono ndi ma antibodies odzipanga okha.

Hashimoto's Thyroiditis - Matenda a autoimmune

Hashimoto's thyroiditis ndi matenda a autoimmune omwe chitetezo cha mthupi chimatsogolera ma antibodies ku chithokomiro chake. Kupezeka kwa ma antibodies amenewa ndiyenso chizindikiro chofunikira cha matendawa.

Minofu ya chithokomiro imawonongeka nthawi zonse ndi kuukira kwa antibody. Zotsatira zake ndi kutupa kosatha komanso kuchepa kwakukulu kwa mahomoni a chithokomiro, mwachitsanzo, hypothyroidism.

Chithokomiro chaching'ono chonga chagulugufe chimakhala kutsogolo kwa khosi ndipo ndichofunika kwambiri pamayendedwe osiyanasiyana. Amapanga mahomoni awiri a chithokomiro T3 (triiodothyronine) ndi T4 (L-thyroxine).

Pituitary gland (chithokomiro chotchedwa endocrine gland mu ubongo) chimatulutsa timadzi toyambitsa matenda a chithokomiro cha TSH kuti chithokomiro chidziwe nthawi yopangira kuchuluka kwa mahomoniwa. Kuchuluka kwa TSH yozungulira m'magazi kumawonetsa chithokomiro ngati T3 ndi T4 ziyenera kupangidwa kapena ayi.

Pamene TSH imakhala yochuluka m'magazi, m'pamenenso thupi limafunikira mahomoni ambiri a chithokomiro.

Komabe, ngati chithokomiro sichingathe kupanga mahomoni okwanira chifukwa cha hypofunction, mlingo wa TSH udzapitirira kukwera. Choncho, Hypothyroidism sichidziwika kokha chifukwa cha T3 ndi T4 yochepa komanso chifukwa cha mtengo wapamwamba wa TSH.

Kukwera kwa TSH kumakwera pamwamba pa mtengo wamba, kutchulidwa kwambiri kwa hypothyroidism kumakhala.

T3 ndi T4 ali ndi udindo wowongolera kagayidwe kathu. Popanda mahomoni a chithokomiro - mwa ana - kukula kwamaganizo kapena thupi sikungatheke.

Kwa akuluakulu, kusowa kwa mahomoni a chithokomiro kumalepheretsa ntchito zosiyanasiyana za thupi. Kugunda kwa mtima ndi ubongo zimatha kuchepa, monganso kugwiritsa ntchito mphamvu kuchokera ku chakudya. Komanso, kusowa kwa mahomoni a chithokomiro kumasokoneza kutentha kwa thupi, kayendedwe ka akazi, ndi kulemera kwake.

Zizindikiro za Hashimoto's thyroiditis zimasiyana mosiyanasiyana: kutopa, kusachita chidwi, kukhudzidwa kwambiri ndi chimfine, kudzimbidwa, matenda am'mimba, khungu louma, tsitsi lopunduka, misomali yopunduka, kunjenjemera, kuyiwala, kuyiwala kukumbukira, kukwiya, kukhumudwa, PMS, nthawi zolemetsa, kunenepa ndi kupweteka kwa minofu ndi mafupa ndi zina mwa zodandaula zofala kwambiri.

Hypothyroidism imathandizidwa ndi mankhwala ochiritsira ndi mankhwala obwezeretsa mahomoni. Odwala a Hashimoto amayenera kumwa mahomoni opangira mapiritsi m'miyoyo yawo yonse kuti apewe zovuta zina (kuphatikizapo goiter, kulephera kwa mtima, ndi chikomokere).

Pakadali pano, madotolo ophatikizana akulimbikitsa kwambiri anthu omwe ali ndi vuto la autoimmune kuti adziyezetse kuti ali ndi vuto lakusalolera zakudya. Mapuloteni amtundu wa gluten makamaka akukayikiridwa kuti amayambitsa chitetezo chamthupi chowononga motsutsana ndi chithokomiro mwa odwala a Hashimoto.

Gluten - Kuukira kwa chitetezo chamthupi

Gluten ndi mapuloteni osakaniza a glutenin ndi gliadin omwe, kuphatikiza ndi wowuma, ndi gawo la tirigu, spelled, rye, balere, oats, emmer, Kamut, ndi mbewu za einkorn. Tirigu ali ndi gilateni kwambiri pafupifupi 50 peresenti.1

Kuphatikiza ndi madzi, gilateni imapangitsa kuti ikhale yolimba, yomata ndipo imatchedwanso mapuloteni a gluten. Puloteni ya gluten iyi imapanga maziko abwino ophikira mkate. Kwa matumbo athu, komabe, ndi tsoka! M'matumbo athu am'mimba, gluten amamanga khoma la matumbo aang'ono. Mavuto a m'mimba ndi matenda a chitetezo cha mthupi tsopano sangapeweke.

Kuwetedwa kwambiri mu gilateni kwa njira zophika mafakitale, tirigu wamakono makamaka amathandizira kuti anthu ambiri amakhudzidwa ndi kusalolera kwa gilateni, komwe kumayenderana ndi matenda osiyanasiyana achiwiri. Gliadin makamaka amaonedwa kuti ndi chifukwa chachikulu cha vutoli.

"Aliyense wa ife ali ndi vuto la gluten"

Asayansi apeza kuti zigawo zina za gliadin zimamangiriza ku zolandilira m'matumbo ndikusokoneza kulumikizana kolimba kwa khoma lamatumbo. Kulumikizana kumeneku nthawi zambiri kumagwirizanitsa maselo ang'onoang'ono a m'matumbo ndikuletsa kuti tinthu tating'onoting'ono ta chakudya zisadutse m'chipupa cha matumbo ndi kulowa m'magazi.

Ngati gliadin iwononga maulumikizidwe, khoma lamatumbo limatha kulowa. Mmodzi amalankhula za zomwe zimatchedwa leaky gut syndrome. Zigawo za chakudya zosakwanira bwino, komanso poizoni tsopano zitha kulowa m'magazi popanda cholepheretsa.

Thupi limawona owukirawo ngati owukira. Ndipo monga nthawi zonse, pamene akumva kuti akuwukiridwa, amayendetsa pulogalamu yake yodzitetezera ndikuyankha "kuukira" ndi chitetezo cha mthupi.

Chitetezo cha mthupi - chomwe chimachitika kale m'matumbo - chimayambitsidwa ndi kupanga maselo ena otetezera (T-cell) motsutsana ndi gliadin yam'manja ndi minofu. Anti-gliadin antibodies (AGA) amapangidwa muchitetezo chachiwiri cha chitetezo.

M'kupita kwa nthawi, chitetezo chamthupi chotsutsana ndi gilateni chimatsogolera ku njira zotupa kwambiri m'matumbo komanso kuwonongeka kwapang'onopang'ono kwa villi m'matumbo ang'onoang'ono. Aliyense amene ali ndi kutupa kosatha ayenera kuchotsa gluten pazakudya zawo nthawi yomweyo.

Madokotala monga Daniel Leffler ochokera ku Harvard Medical School, motero, amachenjeza odwala matenda a celiac okha kuti asadye gluten:

Gluten nthawi zambiri imasiyanitsidwa ndi aliyense. Aliyense wa ife ali ndi zosagwirizana ndi gluten.
Anthu omwe ali ndi ma antibodies okwera kwambiri a gliadin ali pachiwopsezo chachikulu chokhala ndi khansa ya m'mitsempha komanso matenda a autoimmune, makamaka Hashimoto's thyroiditis, matenda a chithokomiro omwe amangodziteteza okha.

Gluten amawonjezera kufunikira kwa mahomoni a chithokomiro

Kafukufuku wochokera ku Roma akuwonetsa kuti odwala a Hashimoto omwe ali ndi vuto la gluten amafunikira 49 peresenti yowonjezera mahomoni a T4 kuti akhale ndi TSH yamtengo wapatali kusiyana ndi odwala omwe alibe tsankho la gilateni.

Pambuyo pa mwezi wa khumi ndi umodzi wa zakudya za gluteni, chofunikira cha T4 cha maphunziro a gluten-sensitive test pa mtengo wovomerezeka wa TSH chinali chofanana kwambiri ndi gulu loyerekeza. Zotsatirazi zikuwonetsanso kulumikizana pakati pa gluten ndi matenda a autoimmune.

Ndizowona kuti odwala a Hashimoto samangodwala matenda a celiac. Komabe, tingaganize kuti ambiri mwa omwe akukhudzidwawo ali ndi mlingo wina wotchedwa gluten sensitivity.

Gluten imapangitsa kuti chitetezo cha mthupi chiwonjezeke

Kaya ndi kukhudzika kwa gluten kapena matenda a celiac, anthu omwe ali ndi matenda a autoimmune monga Hashimoto's thyroiditis amakhala ndi zotsatira zowononga chifukwa cha kuyankha kwamphamvu kwa chitetezo chamthupi.

Pankhani ya matenda omwe alipo kale, chitetezo cha mthupi chimayamba kale. Ndi zakudya zokhala ndi gilateni muzakudya, thupi losamva za gluteni limakhala pamavuto osatha.

Kusasunthika kosalekeza kwa chitetezo chamthupi ku chinthu chosaloledwa cha gliadin pamapeto pake kumakulitsa matenda a autoimmune.

Kutulutsidwa kwa ma antibodies motsutsana ndi mapuloteni a gluten sikungotulutsidwa m'matumbo a m'mimba ndi minofu ya chithokomiro komanso kungayambitse kutupa m'madera ena a thupi, zomwe zimafotokoza zizindikiro zosiyana za kusagwirizana kwa gluten.

Ngakhale kuti anthu ena amakumana ndi kutupa kwa gluten m'magulu awo, ena amakumana ndi vuto la khungu monga zotupa ndi rosacea. Ambiri amamvanso zizindikiro za kutupa muubongo, kumva chifunga m’maganizo mwawo, kuvutika ndi kusinthasintha kwa maganizo, nkhaŵa, ndi kukumbukira kukumbukira.3

Gluten ndi Chithokomiro - The Big Molecular Mix-Up

Kuchuluka kwa chitetezo chamthupi motsutsana ndi gluteni kuchokera ku chakudya komanso motsutsana ndi minofu ya chithokomiro ndi chifukwa cha kufanana kwa maselo pakati pa gliadin yomanga mapuloteni ndi maselo a chithokomiro.

Pamene gluten imalowa m'magazi kudzera m'matumbo otsekemera, chitetezo cha mthupi chimatanthauzira izi ngati kuukira ndikutulutsa ma antibodies. Ma antibodies awa samangolimbana ndi mapuloteni osavomerezeka a gluten gliadin komanso amayika minofu ya chithokomiro yopangidwa mofananamo kukhala yotupa, chifukwa chake minofu imawonongeka komanso kupanga mahomoni kumachepa.

Anthu odwala matenda a chithokomiro akamadya zakudya zokhala ndi gluteni, chithokomiro chimayamba kudwala.

Kusamvana kwa Gluten - kuyezetsa magazi sikolondola

Tsoka ilo, kuyezetsa magazi kokhazikika sikumapereka zotsatira zodalirika kwa odwala a chithokomiro omwe akufuna kuyezetsa kusagwirizana kwa gluten.

Kuyesa kwa ma antibodies kumangoyang'ana gawo linalake la gluteni, lomwe ndi alpha-gliadin. Zina zosiyanasiyana zamagulu a gluten monga omega-gliadin, gamma-gliadin, nyongolosi ya tirigu agglutinin, ndi zina zotero, zomwe zingayambitsenso chitetezo cha mthupi, sizimaganiziridwa.

Pazovuta kwambiri zakusalolera kwa gilateni, kuyezetsa magazi kumalephera kwambiri ndipo motero amawona molakwika kutupa komwe kwayamba kale m'thupi.

Dr Kenneth Fine, mkulu wa zachipatala ku labotale yatsopano ya EnteroLab, amakhulupirira kuti kusanthula kwachimbudzi ndikolondola kwambiri. Njira yoyesera yoyeserera mwapadera yakusalolera kwa gluteni imazindikira ma antibodies omwe amapangidwa m'matumbo asanalowe m'magazi.

Fine anapeza kuti mmodzi mwa anthu atatu aku America ndi osagwirizana ndi gluten. - Mlingo ku Europe uyenera kukhala wofanana. - Mwa anthu 10, 8 angakhale ndi chibadwa cha kusalolera kwa gluten.

Makamaka, anthu omwe ali ndi majini a HLA-DQ amakhudzidwa ndi kusalolera kwa gluten kapena matenda a celiac.

Chifukwa chake, kuzindikirika kolakwika ndi kuphonya malangizo azakudya kumatha kukulitsa thanzi la anthu omwe ali ndi matenda a Hashimoto pang'onopang'ono.

M'nkhaniyi, ngati wina azindikira kuti mbewu zomwe zili ndi gluteni, monga tirigu, ndizo chakudya choyambirira kumayiko akumadzulo, tikulimbana ndi vuto la thanzi la subliminal simmering.

Palibe chifukwa chomveka kuti Hashimoto's thyroiditis ndi amodzi mwa matenda omwe amadziwika kwambiri ndi autoimmune. Monga wodwala wa Hashimoto, ndikofunikira kuti mudziyese nokha wopanda gluteni.

Hashimoto's Thyroiditis - Pamene chitetezo chamthupi chikugunda

Vuto lina pakutsimikizira kusagwirizana kwa gilateni mwa anthu omwe ali ndi matenda a autoimmune amayamba pomwe chitetezo chamthupi chimakhala chofooka kwambiri kotero kuti sichingathenso kupanga ma antibodies okwanira.

Ichi ndi chifukwa china chomwe kuyesedwa kwa gluten kwa odwala a Hashimoto nthawi zambiri kumakhala kolakwika. Ma antibodies amatha kukhala otsika kwambiri kotero kuti mayeso samawawonetsa, ngakhale kuti chitetezo cha mthupi chimawononga minofu chikuchitika mwachinsinsi.

Ponseponse, anthu omwe ali ndi matenda a chithokomiro cha autoimmune amalangizidwa kuti apewe gluten zivute zitani, mosasamala kanthu kuti mayeso akuwonetsa kuyankha kwa antibody kapena ayi. Aliyense amene amadya zakudya zokhala ndi gluteni ngakhale ali ndi matenda odziyimira pawokha omwe amakhudza kwambiri chitetezo chawo chamthupi.

Hashimoto's Thyroiditis - Zakudya zopanda Gluten ndizofunikira

Popeza kukhudzika kwa gluteni komanso kugwirizana kwachindunji pakati pa Hashimoto ndi kusalolera kwa gluten ndikovuta kutsimikizira kugwiritsa ntchito kuyezetsa magazi kwanthawi zonse, madokotala wamba nthawi zambiri amatsutsa zakudya zopanda gluteni pomwe matenda a celiac atha.

Komabe, kafukufuku waposachedwapa amalankhula chinenero chosiyana. Kugwirizana pakati pa matenda a autoimmune (makamaka Hashimoto's thyroiditis) ndi kusalolera kwa gluten ndizodziwikiratu kuti sizinganyalanyazidwe. Akatswiri a autoimmune monga Dr. Datis Kharrazian, motero, amalangiza anthu omwe ali ndi kutupa kwa chithokomiro makamaka kuti azitsatira zakudya zolimbitsa thupi za gluten monga gawo loyamba komanso lofunika kwambiri kuti athetse vutoli.

Chifukwa gluten imagwira ntchito ngati choyambitsa champhamvu chothandizira chitetezo chamthupi mwa odwala ambiri a Hashimoto, mosasamala kanthu za matenda a celiac omwe amapezeka.

Zochitika zikuwonetsa kuti kuchuluka kwa mahomoni ndi zizindikiro za Hashimoto's thyroiditis zimasintha kwambiri mwa ambiri omwe amakhudzidwa ndi zakudya zopanda gluteni. Kusasinthasintha ndikofunikira, komabe. Kukhala wopanda gluteni pang'ono sikutheka kuti apambane monga kukhala ndi pakati pang'ono.

Kuyankha kwa chitetezo chamthupi komwe kumayambitsidwa ndi kumwa kwa gluten kulikonse kumatha mpaka miyezi isanu ndi umodzi. Ngakhale kuluma kochepa kwambiri kwa chakudya chokhala ndi gluten kumapangitsa kuti ma antibodies atulutsidwe kwa nthawi yaitali ndi chitetezo cha mthupi motsutsana ndi minofu ya chithokomiro ndi maselo ena a thupi omwe akhudzidwa.

Kagawo kakang'ono ka keke kapena pasitala m'malesitilanti aku Italiya mwamsanga amatsutsa kupambana kwa chithandizo cha zakudya zopanda gluteni.

Kukhala wopanda gluten m'moyo watsiku ndi tsiku

Tsopano funso lodetsa nkhawa likhoza kubwera ngati zizindikiro za kuchepa sizichitika popanda tirigu monga tirigu ndi co. Chowonadi ndi chakuti chimanga chokhala ndi gilateni mulibe zakudya zilizonse zomwe sizingapezekenso kuchokera ku zakudya zopanda gilateni. Mpunga wa bulauni, quinoa, mapira, buckwheat, amaranth, mbatata, ndi mbatata ndizopatsa thanzi komanso zotetezeka m'malo mwa tirigu wokhala ndi gluten.

Hashimoto - Njira Zonse

Inde, gluten si vuto la Hashimoto lokha. Ndipo zakudya zopanda gluteni sizomwe zimafunikira kuti matendawa athe kuwongolera. Ngakhale kuti mankhwala ochiritsira tsopano amangopereka mahomoni a chithokomiro ndipo mwinamwake amaima mosasamala pamene chithokomiro chimalowa pansi, njira zonse ndi naturopathic zingathandize kwambiri Hashimoto kuti ayime ndipo motero asakhale ndi zizindikiro.