Micah Stanley
Lijo li ama bophelo bo botle ba motho - seo se tsebahala haholo. Ho sa tsejoe hakaalo ke hore na phepo e nepahetseng e etsa sena joang. Ke ’nete hore livithamine le liminerale li thusa ho lula u phetse hantle. Empa hona joale ho fumanoe hore phepo e nepahetseng e bile e susumetsa liphatsa tsa lefutso tsa motho ’me kahoo e ka etsa qeto ea hore na o phetse hantle kapa oa kula. Hobane liphatsa tsa lefutso tse ngata li ka buloa le ho tima. Le hoja lijo tse nang le phepo e nepahetseng li ka fetola liphatsa tsa lefutso tse khothalletsang bophelo bo botle, lijo tsa kajeno li mpa li li tima.
Liphatsa tsa lefutso li laola bophelo bo botle kapa boloetse
Liphatsa tsa lefutso ke likarolo tsa DNA, kapa ho beha taba ka tsela e ’ngoe: DNA e na le liphatsa tsa lefutso tse ngata tse kolokileng haufi le tse ling. Liphatsa tsa lefutso ha li khetholle feela hore na ke batho ba bafe kapa bafe, ponahalo ea rōna le boholo ba ’mele ea rōna. Liphatsa tsa lefutso li laola bophelo ba rona ba letsatsi le letsatsi. Li na le boitsebiso bohle ba lintho tsohle tseo ’mele o itšetlehileng ka tsona le tse hlahisoang ho tsona letsatsi le leng le le leng.
Liphatsa tsa lefutso li tiisa hore lisele tse ncha li lula li bōptjoa, maqeba a fole, moriri oa hōla, mesifa e thehoa, le hore lihomone tse lekaneng, li-enzyme, kapa li-antibodies li thehoa. Liphatsa tsa lefutso ke litaelo tsa motho ka mong bakeng sa tšebeliso. Li bontša kamoo motho ea amehang a sebetsang kateng.
Litaba tsa litaelo tsena tsa tšebeliso kapa liphatsa tsa lefutso ha li fetohe. E hlalosa mesebetsi eohle e robetseng ho batho - e sebetsang, empa le e sa sebetseng.
Empa joale liphatsa tsa lefutso tse sa sebetseng li ne li ka kenngoa tšebetsong, ka mohlala, e le hore tsamaiso ea ’mele ea ho itšireletsa mafung e khone ho sebetsana hamolemo le mathata a macha kapa e le hore ’mele o ka itšireletsa hamolemo khahlanong le tšoaetso. Bakeng sa morero ona, liphatsa tsa lefutso tse sa sebetseng li ka fetoloa - ka tšusumetso e ka ntle, e kang e.g. B. ho tsoa phepong.
Hoo ho sebetsa joang? Hantle-ntle lijo tsa motho li ka ama liphatsa tsa lefutso joang? Lijo li nka tsela e nyane, e leng ka limela tsa mala.
Limela tsa mala li buisana le lisele tsa motho
Ho 'nile ha tsejoa ka nako e telele hore lijo li susumetsa sebopeho sa limela tsa baktheria' meleng. Ha se feela ka libaktheria tse ka maleng (limela tsa mala), empa hape le libaktheria tse ka botšehaling (limela tsa botšehali), libaktheria tse molomong le 'metsong (limela tsa molomo), le libaktheria tse phelang letlalong (limela tsa letlalo). ). Leha ho le joalo, hore na libaktheria tsena kaofela li ama batho ba tsona joang ha ho hlakile.
Bo-rasaense ba Univesithing ea Wisconsin ba se ba fihlile mohatong o mong hape. Ba fumane hore baktheria e buisana le batho ba bona ka lintho tse itseng tsa manqosa - ho latela bafuputsi ka Pulungoana 2016 koranteng e ikhethang ea Molecular Cell. Lintho tsena tsa messenger li ama li-histones tse khubung ea sele. Li-Histones ke lintho tse ka fetolang liphatsa tsa lefutso le ho li tima. (Kakaretso ea li-histones le lintho tse tšoanang li bitsoa epigenome.)
Li-Histones li ka ama mongolo. Sena se bolela ho fetola tlhahisoleseding e bolokiloeng phatsong ea lefutso. Ka mohlala, haeba liphatsa tsa lefutso li na le boitsebiso bakeng sa ho thehoa ha protheine e itseng, joale li-histones li ka susumetsa sebōpeho sena sa protheine.
Sena se bolela hore limela tsa baktheria tsa motho li ka susumetsa liphatsa tsa lefutso tsa motho 'me kahoo boemo ba bona ba bophelo bo botle ka ho susumetsa histones.
Kamoo lijo li amang liphatsa tsa lefutso kateng
Tatelano e tobileng ea tšusumetso e kopanetsoeng e akaretsoa ka tsela e latelang:
- Lijo li laola limela tsa mala
- Lipalesa tsa mala li etsa lintho tse tsamaisang lenģosa
- Lintho tsa Messenger li ama histones
- Li-Histones li kenya tšebetsong liphatsa tsa lefutso
- Liphatsa tsa lefutso li etsa qeto ea hore na batho ba phetse hantle kapa baa kula
Hape ho se ho ntse ho tsejoa hore tšusumetso ena ha e ame feela liphatsa tsa lefutso tse haufi le limela tse amehang. Ka hona, limela tsa mala li ke ke tsa susumetsa feela ho ngoloa ka maleng, empa hape le likarolong tse fapaneng ka ho feletseng tsa 'mele, mohlala, sebeteng le liseleng tsa adipose.
Ena ke ea pele ea seo re tšepang hore e tla ba lithuto tse ngata tse nang le temohisiso tse tla re thusa ho hlakisa kamano pakeng tsa limela tsa mala le phello ea tsona bophelong ba batho. "
ho bolela Dr John Denu, moprofesa oa k'hemistri ea biomolecular Univesithing ea Wisconsin, Madison, e mong oa bangoli ba phahameng ba thuto.
Phepo e laola liphatsa tsa lefutso ka limela tsa mala
Ho ne ho thahasellisa ho bona hore na lijo li na le karolo e kae mona. Haeba u bapisa lijo tse leka-lekaneng (litholoana tse ngata, meroho, le fiber) le lijo tse tloaelehileng tsa Bophirimela, ke hore, "tloaelo" ea lijo (e fokolang ka fiber, mafura a mangata le tsoekere), ha ho letho le lecha le ileng la hlaha:
Limela tsa mala a batho ba feptjoang ka tloaelo li ne li fapane haholo le tsa barupeluoa ba jang bophirimela, ho ea ka Dr. Federico Rey, motlatsi oa moprofesa oa bacteriology. Lijo tse nang le fiber e ngata li fana ka limela tsa mala ka limatlafatsi tse ling tse ngata e le hore ho ka ba le limela tse ngata tse phetseng hantle tsa mala. Hase feela hore libaktheria tse ngata tsa mala li thehoa, empa mefuta e mengata e mengata ea likokoana-hloko e boetse e hlaha, ke hore mefuta e mengata e fapaneng ea libaktheria.
Ka lebaka leo, ka lijo tse phetseng hantle tse thehiloeng ho semela, lintho tseo - joalo ka ha ho hlalositsoe ka holimo - li ka ba le phello ho li-histones le tsona li hola haholo. Ho ne ho se joalo ka lijo tsa Bophirimela.
Lintho tsa messenger tsa limela tsa mala: li-short-chain fatty acids
Hona joale rea tseba hore lintho tsena - li-short-chain fatty acids (mohlala, butyric acid le propionic acid) tse entsoeng ke limela tsa mala ka pel'a fiber - li bohlokoa haholo bakeng sa tšusumetso e hlalositsoeng liphatseng tsa lefutso," ho boletse. Denu.
Haeba u file batho ba liteko ba se nang limela tsa intestinal short-chain fatty acids e le tlatsetso ea lijo, ho bile le liphetoho tse ntle tsa liphatsa tsa lefutso tse tšoanang le tsa batho ba neng ba lekoa ba neng ba e-na le phepo e nepahetseng.
Tabeng ena, ke khale ho tsejoa hore batho ba nang le lefu la tsoekere le mafu a pelo le methapo ea mali ba na le limela tsa mala tse etsang li-acid tse fokolang haholo ho feta batho ba phetseng hantle. Sena se fosahetse le ho feta hobane li-acid tse khutšoane tsa mafura le tsona li na le phello e khahlanong le ho ruruha - 'me lefu la tsoekere le mafu a pelo haholo ke a mang a mafu a sa foleng a ho ruruha.
Li-polyphenols le tsona li susumetsa liphatsa tsa lefutso
Leha ho le joalo, motho ha aa lokela ho nka li-acid tse khutšoane tsa mafura e le tlatsetso ea lijo - ho latela bafuputsi. Ho molemo haholo ho ja litholoana le meroho haholo. Hobane tsena li na le lintho tse ngata ho feta fiber (tseo limela tsa mala li ka hlahisang li-acid tse khutšoane tsa mafura). Li-polyphenols li boetse li fumaneha lijong tse phetseng hantle tse nang le meroho le litholoana. Tsena li boetse li na le metabolized ka maleng 'me li ka ba le phello e ntle ho chromatin (karolo ea DNA).
Ka hona, liphuputso tse mabapi le litlamorao tsa li-acid tse khutšoane tsa mafura e mpa e le ntlha ea leqhoa e ntseng e hloka ho hlahlojoa sebakeng sa phepo le hore na e ka ama liphatsa tsa lefutso tsa motho joang.
Kenya liphatsa tsa lefutso tsa hau ka lijo tse phetseng hantle
Leha ho le joalo, 'nete ke hore lijo tse phetseng hantle tse thehiloeng ho limela le limela tse nang le litholoana le meroho tse ngata li susumetsa limela tsa mala ka tsela eo li ka hlahisang mafura a itseng a mafura, ao hona joale a lebisang liphetohong tsa lefutso. Liphetoho tsena, le tsona, li ka thusa batho ho ikamahanya hamolemo le maemo a hona joale a tikoloho le ho lula ba phetse hantle.
Kahoo joale re na le karolo e 'ngoe ea papali ka pel'a rona e pakang hore na ho bohlale hakae ho ja lijo tse phetseng hantle le ho iphepa ka lijo tse nang le litholoana le meroho e ngata.
