Emma Miller
Ikomityi nganye eyongezelelweyo esetyenzisiweyo yonke imihla inciphisa umngcipheko wophuhliso. Ikofu inokukunika ukungcangcazela, kodwa inokunciphisa umngcipheko wakho wokuphazamiseka kwesigqi sentliziyo - okanye "i-arrhythmias" - uphononongo olothusayo lufunyenwe. Abaphandi kwiYunivesithi yaseCalifornia, eSan Francisco bahlalutye umphumo wokusetyenziswa kwekhofi kwiziganeko ze-arrhythmias kubantu abangaphezu kwe-380000.
Bafumanise ukuba ikomityi nganye eyongezelelekileyo etyiwa yonke imihla inciphisa amathuba okuba nesingqi sentliziyo esingaqhelekanga ngesi-3 ekhulwini. Uphononongo lwenziwe yi-bioengineer kuJung Kim weYunivesithi yaseCalifornia, eSan Francisco, kunye noogxa bakhe. "Kolu phando lweqela elilindelekileyo, ukunyusa umthamo wokusetyenziswa kwekofu okuqhelekileyo kwakunxulumene nomngcipheko ophantsi we-arrhythmia," abaphandi babhala kwinqaku labo.
Bongezelela ngelithi, le nto yayiyimeko, “ingakumbi kwi-atrial fibrillation kunye ne-supraventricular tachycardia, ngaphandle kobungqina bokuba umahluko omiselwe ngokwemfuza kwimetabolism ye-caffeine iguqule le mibutho. "Ukuvalwa ngokubanzi kwe-caffeine ukunciphisa umngcipheko we-arrhythmia mhlawumbi akufuneki."
Kuphononongo lwabo, uKim kunye noogxa bahlalutya idatha kwimpilo, imfuzo, kunye nemikhwa yokusetyenziswa kwekofu yabathathi-nxaxheba be-386,258 malunga nexesha elimalunga ne-5 iminyaka. Idatha yophononongo iqokelelwe yi-UK Biobank, i-database enkulu equlethe ulwazi olucacileyo lwezofuzo kunye nempilo kwisiqingatha sesigidi sabathathi-nxaxheba.
Ngethuba lokulandelelana kwexesha, abathathi-nxaxheba be-16,979 bafumanisa ukuba bane-episodic arrhythmia. Emva kokulungelelanisa izinto eziphazamisayo ezifana ne-demographics, i-comorbidities, kunye nemikhwa yokuphila, iqela lifumene ukuba indebe nganye yekofu eyongezelelweyo iyanciphisa umngcipheko we-arrhythmia nge-3%.
Uhlalutyo olongezelelweyo lubonakalise ukuncipha okufanayo ngokwezibalo kumngcipheko we-fibrillation ye-atrial kunye ne-supraventricular tachycardia, ngokukodwa. Kwinxalenye yokugqibela yophononongo, iqela liphande ukuba ngaba iintlobo ezisixhenxe ezahlukeneyo zofuzo ziyaziwa ukuba zichaphazela i-caffeine metabolism yatshintsha ubudlelwane phakathi kokusetyenziswa kwekofu kunye nomngcipheko we-arrhythmia, ukugqiba ukuba akukho nto.
Ulingo olungenamkhethe lweMendelian olubandakanya ukwahluka kofuzo ngokufanayo alufumananga nxulumano phakathi kokwahluka kwimetabolism ye-caffeine kunye nomngcipheko wokuphuhlisa ukuphazamiseka kwesigqi sentliziyo.
