Lindy Valdez
Ukunqongophala kwe-Vitamin D kuqhelekileyo kwizifo ezizimelayo. Kodwa ngaba oko kuthetha ukuba ukuthatha ivithamin D kunokuphucula isifo? Ngenxa yokuba ukulawulwa kwe-vitamin D kwizifo ezizimele zihlala zingenasiphumo. Sichaza ukuba yintoni isizathu sokuba oku kunye nendlela yokwenza kule meko.
I-Vitamin D: Ibalulekile kwizifo ezizimele
Izifo ezizisebenzelayo zizifo ezingapheliyo zokudumba ekuhambeni kwexesha apho amajoni omzimba ahlasela iiseli kunye namalungu awo ngempazamo- kwaye ayisajongi ngokukodwa kwiibhaktheriya eziyingozi, iintsholongwane, njl.
Ukusuka kwindawo yokujonga iyeza eliqhelekileyo, ngelishwa alikho ithuba lokunyanga izifo ezizimelayo. Noko ke, unyango olupheleleyo luzisa isiqabu phantse kuzo zonke iimeko yaye ngokufuthi lude lumise esi sifo. I-Vitamin D yinxalenye ebalulekileyo yonyango olunjalo lwe-naturopathic ukuba inqanaba le-vitamin D libonakaliswe liphantsi kakhulu. Nantsi indlela yokunyanga izifo ze-autoimmune ngokwemvelo.
Ukunqongophala kwe-vitamin D kunokukhuthaza njani izifo ezizimele
I-Vitamin D inxulumene ngokusondeleyo kwiinkqubo ezininzi zebhayoloji ezilawula amajoni omzimba. I-Vitamin D i-receptors ifunyenwe kwinani leeseli zomzimba, umz. B. monocytes, iiseli ze-dendritic, kunye neeseli ze-T ezisebenzayo, ezibonisa ukuba i-vitamin D idlala indima ekuphuhliseni okanye ekuthinteleni izifo ezizimele. Impembelelo echasayo ye-vitamin D nayo yaziwa ixesha elide.
Ngokophononongo olucacileyo oluvela kwi-2013, ukungabikho kwe-vitamin D kunokuphazamisa ukunyamezela kwabantu abane-genetic predisposition kwaye ngaloo ndlela kukhuthaze ukuphuhliswa kwezifo ezizimele. Ukuzinyamezela kukukwazi kwenkqubo yomzimba yokuzikhusela ekuqondeni izinto ezakha umzimba ngolo hlobo kwaye zikwazi ukwahlula kwizinto ezingaziwayo emzimbeni ukuze kungenzeki ukuhlaselwa kwezicubu zomzimba.
I-Vitamin D inciphisa umngcipheko wezifo ezizimele
Kuphononongo olupapashwe kwiBritish Medical Journal BMJ ngoJanuwari 2022, kusetyenziswa phantse izifundo ezingama-26,000, kwaboniswa ukuba ivithamin D inokunciphisa umngcipheko wezifo ezizimelayo ngepesenti ezingama-22.
Abo bantu bovavanyo ababethathe i-2000 IU ye-vitamin D ngosuku baye bahlakulela isifo esizimelayo ngokuphawulekayo ngaphantsi kwexesha lokufunda iminyaka emi-5 kunabathathi-nxaxheba abaye bafumana ukulungiswa kwe-placebo.
Kutheni i-vitamin D ngamanye amaxesha ingasebenzi
I-Vitamin D iphandiwe kumxholo we-multiple sclerosis ukususela kwi-1980s. Izifundo zokuqala zenziwa ngamaxabiso aphantsi e-vitamin D, ebonisa ukuba akukho mphumo. Kuphela kwiminyaka yakutshanje kukho izifundo apho iidosi eziphezulu ze-7,000 ukuya kwi-14,000 IU ye-vitamin D ngosuku zazilawulwa, kodwa ubukhulu becala kungekhona kwiidosi zemihla ngemihla, umz. Kodwa nangona kunjalo, ngokufuthi kwakungaphumeleli.
Izazinzulu malunga neyeza lothintelo uProf. Dr. Ngo-Epreli ka-2021, u-Jörg Spitz wapapasha ulwazi oluphangaleleyo malunga noxhathiso lwevithamin D, enokuba sesinye isizathu sokuba ukuthatha izixa eziqhelekileyo ze-vitamin D kwizifo ezizimelayo (kunye nezinye izifo) zihlala zingenasiphumo. Ewe, ngokukaProf. Spitz, ukunganyangeki kwe-vitamin D kunokuba ngunobangela wezifo ezizimelayo.
Ukumelana ne-Vitamin D
Kwimeko yokumelana ne-vitamin D, iiseli zisabela kuphela ngokubuthathaka kwi-vitamin D, umz. enokuthi ibe ngenxa yokuvaleka kwento ebizwa ngokuba yi-vitamin D receptor pathway (izifo ezosulelayo zixutyushwa njengonobangela wokuvaleka). Ii-receptors ze-Vitamin D zingaphakathi kweeseli. Xa ivithamin D ibophelela kwi-receptor, inokuvula okanye ivale iijini ezithile kwiiseli ukuqalisa iziphumo eziqhelekileyo ze-vitamin D, kodwa ukuxhathisa akwenzi.
I-Vitamin D yonyango lwedosi ephezulu
Nangona kunjalo, ukuxhathisa kwe-vitamin D kubuyiselwa umva - kunye needosi eziphezulu ze-vitamin, D. Ukufumana i-vitamin D ukuxhathisa (okungeyokuzalwa kodwa kwenzeka kuphela ngexesha lokuphila) kusathathwa njengengcamango, kodwa uProf Spitz sele enamava athembisayo kwintsimi ye-multiple sclerosis, ukwenzela ukuba iingcebiso zakhe ziphulaphule ngokuqinisekileyo kufuneka zibe.
UProf. Spitz usebenzisa into ebizwa ngokuba yi-Coimbra protocol - isikimu sokuthatha ivithamin D esaphuhliswa yingcali yemithambo-luvo yaseBrazil uCicero G. Coimbra. I-Coimbra Protocol ikwabonelela ngeedosi ezahlukeneyo zevithamin D kwizifo ezahlukeneyo ze-autoimmune. Olu lwazi lulandelayo lujongwe kuphela njengesishwankathelo sokuqala. Xoxa ngeyona ndlela ilungileyo yokwenza nogqirha wakho.
Inkqubo yeCoimbra
Idosi yokuqala yeCoimbra protocol yile:
- I-1000 IU ngekhilogram yobunzima bomzimba kwi-multiple sclerosis
- 300 – 500 IU ngekhilogram yobunzima bomzimba kwi-rheumatoid arthritis (rheumatism), systemic lupus, psoriatic arthritis, psoriasis, Crohn’s disease, ulcerative colitis
- I-300 IU ngekhilogram yobunzima bomzimba kwi-Hashimoto's, i-ankylosing spondylitis, i-systemic scleroderma
- I-150 IU ngekhilogram yobunzima bomzimba kwezinye izifo ze-autoimmune
Ke ukuba unesifo esizimelayo okanye ufuna ukusikhusela, jonga amanqanaba akho evithamin D kwaye uthathe ivithamin D ukuba uyasilela.
Thintela iziphumo ebezingalindelekanga ze-vitamin D yonyango lwedosi ephezulu
Ngonyango lwedosi ephezulu, kusoloko kubalulekile ukubekwa iliso elibukhali ngugqirha ukuze kuthintelwe iziphumo ebezingalindelekanga (umz. hypercalcemia).
Kwi-hypercalcemia, i-vitamin D ibangela ukuba i-calcium engaphezulu ifunxwe emathunjini ukuya egazini. Ngoko ke, izinga le-calcium egazini (serum) kunye nomchamo lijongwa rhoqo. Kakade ke, isigulane kufuneka sinikele ingqalelo kwiimpawu eziqhelekileyo ze-hypercalcemia (amanqanaba aphezulu e-calcium). Oku kuquka ukuchama rhoqo xa unxanwe kakhulu, ukudinwa okungaqhelekanga, okanye kwanokuqhina.
Ukutya okune-calcium ephantsi kubalulekile kwiProtocol yeCoimbra ukuphepha ukugqithisa kwe-calcium.
Izilumkiso kwi-intanethi malunga neProtocol yeCoimbra zisekelwe kwiingxelo zeemeko ezizimeleyo ezijongene ne-hypercalcemia ekhankanywe, enokuthintelwa ngamanyathelo akhankanywe. Ngezilumkiso zolu hlobo, iingenelo ze-vitamin D zonyango lwe-dose ephezulu zihlala zingahoywa, njengemiphumo emibi yonyango oluqhelekileyo.
