Pono ka Vitamin D i ka Vitamin A

Pono ka Vitamin D i ka huaora A i mea e loaʻa ai ka hopena maikaʻi loa. ʻO ka lawe ʻana i ka huaʻa A i ka manawa like e piʻi nui ai ka pae o ka huaʻa D ma mua o ka lawe ʻana i ka huaʻa D wale nō. ʻO ka hui pū ʻana o nā huaora ʻelua i hiki ke hōʻemi nui i nā pae ʻona ma hope o ka hahau ʻana. Ua ʻoi aku ka maikaʻi o ka hana hou ʻana o ka lolo i ka wā i lawe ʻia ai nā huaora ʻelua.

Huaola D: ʻOi aku ka bioavailability ma o ka huaora A

Ua ʻike lōʻihi ʻia ʻoi aku ka maikaʻi o ka lāʻau D me ka magnesium a me ka huaora K2. Hoʻonui ka Magnesium i ka hopena o ka huaora D - a ʻo ka huaora K2 e hōʻoia i ka hāʻawi pono ʻana o ka calcium, ka mea, mahalo i ka huaʻa D, hiki ke komo maikaʻi ʻia mai ka ʻōpū.

Eia kekahi, ua hōʻike ʻia i ka lawe ʻana i ka vitamina D, pono kekahi e noʻonoʻo i ka vitamina A. Hiki ke hoʻomaikaʻi i ka bioavailability o ka vitamin D, e like me ka haʻawina randomized, controlled, a me ka makapō hoʻokahi mai ʻAukake 2020 (1). Ua nānā ʻo ia i nā hopena o ka huaora A a me ka huaora D i nā poʻe maʻi i loaʻa i ka hahau.

Manaʻo ʻia ʻo ka hahau ʻana he mea kaumaha nui - ʻaʻole wale no ka poʻe i hoʻopilikia ʻia akā no ka ʻōnaehana olakino. Ke alakaʻi pinepine nei kēia i ka pōʻino lolo hiki ʻole ke hoʻololi ʻia, ke kīnā mau loa, a me nā hana hoʻoponopono lōʻihi.

No ke aha nā huaora no ka hahau ʻana?

Ke ʻimi nei ka poʻe i nā lāʻau lapaʻau a me nā mea hana e hoʻoikaika ai i ka hoʻōla hou ʻana ma hope o ka hahau ʻana a mālama i ka pōʻino i ka lolo i ka liʻiliʻi. Ke ulu nui nei nā huaora a me nā minela.

Loaʻa ka hapa nui o nā hahau ma muli o ka arteriosclerosis (nā waiho i loko o nā kīʻaha koko/nā kīʻaha koko paʻakikī) a i ʻole ka thrombosis. ʻO ka hāʻawi ʻole ʻana o ka huaora D a me ka huaʻa A e hoʻonui i ka pilikia o ka arteriosclerosis a pēlā pū kekahi o ka hahau. E pili ana kēia: ʻo ka haʻahaʻa o ka nui o ka huaora A a me ka pae D, ʻoi aku ka nui o ka pilikia o ka ulu ʻana i ka maʻi cardiovascular.

Ma ka ʻaoʻao ʻē aʻe, inā hoʻolako maikaʻi ʻia ʻoe me ka vitamina A a me ka vitamina D, hiki i nā huaora ʻelua ke hoʻolohi i ka ulu ʻana o arteriosclerosis mahalo i kā lākou hopena anti-inflammatory a antioxidant.

Vitamin A i ka hahau

Hoʻopili ʻia ka Vitamin A a me kāna mau metabolites i ka pale ʻana i ka pale koko-lolo, ma laila e hōʻemi ai i ka nui o ka pōʻino i hiki ke hopena mai ka hahau ʻana.

Hana pū nā mea loaʻa Vitamin A me nā mea loaʻa ʻē aʻe i loaʻa ka hopena neuroprotective, e like me. ʻO B. me nā mea hoʻokipa vitamin D. I ka hihia o nā huaora A a me D, ʻo nā mea loaʻa nā hale i loko o ke kelepona. Hoʻopili ʻia nā huaora e pili ana ma ʻaneʻi a laila e hoʻomaka i kā lākou hopena kikoʻī. ʻIke ʻia ka hui like ʻana me nā mea loaʻa huaʻai A i hoʻāla ʻia e ka nui o ka huaora A e hoʻoikaika i ka hana o nā mea loaʻa huaʻai D a me ka hope.

Vitamin D i ka hahau

Ua hōʻike ʻia kahi haʻawina 2015 o nā maʻi 818 i ʻoi aku ka maikaʻi o ka poʻe me nā pae kiʻekiʻe o ka huaora D i ko lākou hahau ʻana ma mua o ka poʻe me nā pae haʻahaʻa o ka huaora D. No laila hiki ke hoʻohana ʻia nā pae Vitamin D ʻaʻole wale ma ke ʻano he hōʻailona no ka pilikia o ka maʻi cardiovascular a me ka make akā no ke ola ʻana i kahi hahau.

I ka makahiki 2017, ua hōʻike mākou ma kahi noiʻi (Vitamin D Repairs Blood Vessels Instantly) kahi i komo ai nā poʻe i hōʻike mua i nā hōʻailona o ke aʻaʻa paʻakikī i lawe i ka 4,000 IU o ka huaora D i kēlā me kēia lā. Ma hope o 4 mahina, ua emi ka paʻakikī o nā aʻa. Hōʻike ka ʻatikala i hoʻopili ʻia i nā ʻano hana e pale ai ka huaora i nā aʻa.

Haʻawina: Pehea ka hoʻoikaika ʻana o ka huaora A a me ka huaora D kekahi i kekahi

Ma ke aʻo ʻana mai ʻAukake 2020 i ʻōlelo ʻia ma ka hoʻomaka, 120 mau mea maʻi maʻi i komo. Ua loaʻa iā lākou a pau i ka maʻi ʻeha ischemic a ua ʻike ʻia i loko o 3 mau lā. Ua mālama ʻia lākou me nā lāʻau lapaʻau maʻamau a loaʻa iā lākou ka lāʻau lapaʻau kino.

Loaʻa ka maʻi ischemic ma muli o ka arteriosclerosis a i ʻole ka thrombosis, ʻo ia hoʻi ma muli o kahi kīʻaha koko i hoʻopaʻa ʻia a ʻaʻole - e like me ke ʻano o ka maʻi hemorrhagic - ma muli o ka hemorrhage cerebral. ʻO ka hapa nui o nā hahau he ischemic ma ke ʻano.

Hiki i nā huaora ke kōkua i ka hoʻoponopono hou ʻana i ka stroke?

I mea e ʻike ai inā a pehea e hana ai nā huaora A a me D i ka hoʻihoʻi ʻana i ka hahau, ua māhele ʻia nā mea komo i kēia haʻawina i 4 mau pūʻulu:

• Ua loaʻa i ka hui vitamina A he 50,000 IU (= 15 mg) o ka huaʻa A i hoʻokahi manawa i ka pule (e like me 90 mg o ka beta carotene)
• Ua loaʻa i ka hui vitamin D 50,000 IU (= 1250 µg) o ka huaʻa D3 i hoʻokahi manawa i ka pule.
• Ua loaʻa i ka hui i hui pū ʻia he 50,000 IU i kēlā me kēia o ka huaora A a me ka huaora D3 i hoʻokahi manawa i ka pule
• Ua loaʻa i ka hui placebo kahi hoʻomākaukau placebo i hoʻokahi pule

Lawe ʻia kēlā me kēia lāʻau lapaʻau no 12 pule. I ka hoʻomaka ʻana o ke aʻo ʻana - ʻo ia hoʻi i ka manawa o ka hōʻike ʻana i ka hahau a ma mua o ka lawe ʻia ʻana o nā huaora - ua ʻike ʻia kahi pae vitamin D ʻole i nā maʻi āpau (awelika 20.75 ng/ml). ʻO ka pae maʻamau o ka vitamina A, ma kekahi ʻaoʻao, he maʻamau (422.9 μg/l).

Ma hope o ʻekolu mahina, ua loaʻa nā hopena penei:

Hoʻoikaika ka Vitamin D i ka absorption o ka vitamina A

I loko o ka hui vitamina A a me ka hui i hui pū ʻia, ua piʻi ka pae o ka huaora A. ʻAʻole i lawe nā hui ʻelua (ʻaʻole lākou i lawe i ka vitamina).

I loko o ka hui hui pū ʻia, ua piʻi nui ka pae o ka huaora A ma mua o ka hui ʻana o ka huaora A, me ka manaʻo e hāpai ka vitamina D i ka absorption o ka vitamina A.

I loko o ka hui vitamina A, piʻi ka pae mai 476 a 498 µg/l, a ma ka hui hui mai 462 a 511 µg/l.

Hoʻoikaika ka Vitamin A i ka absorption o ka vitamin D

I loko o ka hui vitamina D a me ka hui i hui pū ʻia, ua piʻi nui ka pae o ka vitamina D. Ma nā hui ʻelua, ua hāʻule iki.

Ua hoʻonui ʻia ka nui o ka Vitamin D ma 12 pakeneka ma mua o 12 pule i ka wā i lawe wale ʻia ai ka huaora D, ʻoiai ua hoʻonui ʻia e 30 pākēneka i ka wā i lawe pū ʻia ai nā huaora ʻelua. No laila, ʻaʻole hoʻoikaika wale ka huaora D i ka absorption o ka vitamina D. ʻO ia hoʻi ke ala ʻē aʻe: ʻo ka vitamina A kekahi e hāpai i ka absorption o ka vitamina D.

ʻO ka hui pū ʻana o nā huaora e hoʻemi maikaʻi i nā pae ʻona

Hoʻopili mau ʻia ka Arteriosclerosis me nā kaʻina hana inflammatory mau, hiki ke hoʻoholo ʻia e ka hoʻonui ʻana i nā pae o nā mea ʻelele pro-inflammatory. ʻO Interleukin-1β (IL-1β) he ʻelele inflammatory i hoʻohana ʻia ma ke ʻano he hōʻailona no ka arteriosclerosis. ʻO ke kiʻekiʻe o ka waiwai IL-1β, ʻoi aku ka nui o ka haʻi ʻana o ka arteriosclerosis a ʻoi aku ka kiʻekiʻe o ka pilikia o ka hahau.

ʻAʻole hiki ke ʻike ʻia ka ʻelele inflammatory interleukin-1 (IL-1) i loko o ka lolo olakino; inā loaʻa ka lolo ma muli o ka maʻi (eg. ʻO ka Vitamin D kekahi o ia mau meaʻai e pāʻani nui ana i ka maʻi hahau ʻana no ka mea ʻo ka huaora i lalo e hoʻoponopono i ka mumū, e laʻa me kona hopena i ka interleukin.

Ma ka haʻawina i luna, ua emi ka pae o IL-1β i ka hui vitamin D a me ka hui hui. I ka hui vitamin D, ua hāʻule mai ka 0.3 a i ka 0.27 pg / ml, i ka hui hui ua hāʻule nui loa ia, ʻo ia hoʻi mai 0.49 a 0.21 pg / ml.

Ma ka hui vitamina A, ma kekahi ʻaoʻao, ua piʻi iki mai ka 0.47 a i ka 0.49 pg/ml. I ka hui placebo, ua hoʻonui nui ʻia mai ka 0.43 a i ka 0.79 pg/ml.

Me he mea lā e kākoʻo maopopo ana ka Vitamin A i ka hopena anti-inflammatory o ka huaʻai D ma ʻaneʻi, ʻoiai ʻaʻohe ona hopena pili iā ia iho.

Hui Huaola: ʻOi aku ka maikaʻi o ka hoʻihoʻi ʻana i ka maʻi

Hiki ke hoʻohana ʻia ka National Institutes of Health Stroke Scale (NIHSS) e nānā i ka paʻakikī o kahi hahau. Aia kēia pālākiō he 5 pae:

• 0 ʻaʻohe hōʻailona hahau
• 1-4 mau hōʻailona liʻiliʻi
• 5-15 mau hōʻailona haʻahaʻa
• 16-20 mau hōʻailona maʻamau a koʻikoʻi
• 21 - 42 mau hōʻailona ikaika

Ma ka haʻawina i kēia manawa, hāʻule ka helu NIHSS i ka nui o ka hui i hui pū ʻia, e hōʻike ana i ka hāʻawi ʻana i nā huaora ʻelua i ka wā o ka hahau ʻana ʻo ia ka hana maikaʻi loa a loaʻa ka hopena maikaʻi loa. ʻO nā hopena kikoʻī penei:

• Huaola A: E hāʻule ana ka waiwai NIHSS mai ka 12.1 a i ka 10.3
• Huaʻai D: hāʻule ka waiwai NIHSS mai ka 13.2 a i ka 10.4
• Huaola A a me D: hāʻule ka helu NIHSS mai 13.25 a i 6
• Placebo: Ua hāʻule ka helu NIHSS mai 13.15 a i 11.75

Hana maikaʻi wale ka Vitamin D me ka huaora A

ʻO ka hopena vitamin D maikaʻi loa e hiki ke loaʻa i ke alo o ka huaora A. Ua kākau nā ʻepekema:

ʻO ka hui pū ʻana o nā huaora A a me D e hōʻemi i ka arteriosclerosis

No ka mea ua manaʻo ʻia ʻo IL-1β he māka no ka hoʻomohala ʻana i ka arteriosclerosis a ua hāʻule kēia waiwai i ka haʻawina o kēia manawa, kākau nā mea noiʻi: "ʻO kā mākou hopena e hōʻike ana i ka hoʻohana like ʻana o ka vitamina D a me ka vitamina A synergistically (hoʻoikaika i kekahi) e hōʻemi i ka arteriosclerosis a pale i ka nā paia vascular ma ke kāohi ʻana i ke kaumaha oxidative a me ka mumū. ʻO ka hui pū ʻana o nā huaora ʻelua, no laila, he ala hoʻohiki i ka lāʻau lapaʻau a me ka pale ʻana i ka arteriosclerosis.

Ka hopena: ʻoi aku ka maikaʻi o ka lawe ʻana i ka Vitamin D me ka huaʻa A

Ke hoʻohālikelike ʻia me ka poʻe i ola i ka hahau ʻana i loaʻa wale i ka lāʻau lapaʻau maʻamau a me ka hoʻōla kino, ʻoi aku ka maikaʻi o ka poʻe i ola i ka maʻi maʻi i loaʻa pū i nā huaora A a me D.

ʻAʻole pono nā kiʻekiʻe kiʻekiʻe o ka huaora A i ʻōlelo ʻia ma luna nei no ka pale ʻana a i ʻole ka hāʻawi ʻana i kēlā me kēia lā o ka huaʻa D.

Ma kā mākou ʻōlelo aʻoaʻo no ka hoʻomaikaʻi ʻana i kāu lako vitamina D, e ʻike ʻoe i nā ʻike āpau āu e pono ai e pale aku i ka hana hewa ʻana i ka lawe ʻana i ka huaora D.

Ua lawa anei nā huaora no ka pale ʻana i ka stroke?

ʻOiaʻiʻo, ʻo ka lawe ʻana i nā huaora wale nō ʻaʻole hiki ke hōʻoia i ka pale ʻia ʻana o ka hahau ʻana a i ʻole hiki ke hoʻokō maʻalahi i kahi hahau i hana ʻia. Nui nā kumu ʻē aʻe e hoʻololi i ka pilikia o ka arteriosclerosis a me ka hahau ʻana a me ka papa o ka hoʻoponopono ʻana ma hope o ka hahau ʻana, e laʻa me B. ke kumukānāwai nui, ka meaʻai, ka hoʻomaʻamaʻa kino, a me nā mea ʻē aʻe. e like me ka hiki.

No ka mea, ua ʻōlelo pinepine ʻia ʻaʻole pono ka poʻe puhi paka e lawe i ka beta-carotene no ka mea hiki ke hoʻonui i ko lākou pilikia o ka maʻi kanesa, makemake mākou e lawe i kēia manawa e hoʻi i kā mākou ʻatikala He kumu anei ka beta-carotene i ka maʻi kanesa? e hōʻike i ka puhi wale ʻana i mea pilikia nui no ka hahau ʻana a me nā maʻi maʻi cardiovascular ʻē aʻe. No laila, inā he puhi paka ʻoe, ʻo kāu hana mua a koʻikoʻi ka hoʻōki ʻana i ka puhi paka. Ma ʻaneʻi ʻoe e ʻike ai i nā ala holoʻokoʻa mai ka addiction.

Hiki iā ʻoe ke loaʻa ka huaora A mai ka meaʻai?

ʻAʻole i loaʻa i nā meaʻai mea kanu ka huaora A akā aia ka huaʻa A precursor beta-carotene. Mai kēia, hiki i ke kino ke hana i ka nui o ka huaora A e pono ai iā ia iho no laila ʻaʻole hiki ke overdose o ka huaora A i kēia hihia (ʻo ia me nā meaʻai holoholona).

Eia nō naʻe, pono e ʻai ʻia ka beta-carotene, no ka mea, ma kahi o 6 a 12 mg o ka beta-carotene e koi ʻia no 1 mg o ka huaora A, ʻo ia hoʻi he 6 a 12 mau manawa ka nui.

Loaʻa ka Beta-carotene i loko o nā lau ʻōmaʻomaʻo ʻeleʻele a me ka ʻalani (ʻukena, kale, spinach, letus hipa, ʻulaʻula, kāpeti savoy, a me kāloti). ʻO 100 g kāloti, aia ma waena o nā kumu maikaʻi loa o ka beta-carotene, aia ma kahi o 8 mg o ka beta-carotene. Eia naʻe, ʻokoʻa ka bioavailability o ka beta-carotene mai nā kāloti (a me nā mea kanu ʻē aʻe). Hiki ke piʻi i ka 3 pakeneka, akā me ka hoʻomākaukau kūpono, hiki ke piʻi i ka 45 pakeneka. E heluhelu i kā mākou ʻatikala e pili ana i nā kāloti pehea e hoʻomākaukau pono ai i ka mea kanu.