John Myers
Kupsinjika maganizo kumatha kukudwalitsani ndikuyambitsa zizindikiro zambiri, koma makamaka ku zovuta za m'mimba monga flatulence, kutsegula m'mimba, kapena zizindikiro zofanana ndi matenda opweteka a m'mimba. Kafukufuku wosiyanasiyana akuwonetsa kuti ma probiotics enieni amathandiza chamoyo kuthana ndi kupsinjika.
Ma Probiotics a Kupsinjika Maganizo
Ma probiotics ndi kuphatikiza kwa mitundu yosiyanasiyana ya mabakiteriya, omwe nthawi zambiri amatengedwa ngati makapisozi kapena ufa. Amapangidwa kuti apange matumbo athanzi. Chifukwa kokha ndi zomera wathanzi m'matumbo anthu akhoza kukhala athanzi. Kumbali inayi, kusalinganika kwa zomera za m'mimba kungayambitse matenda ambiri osiyanasiyana.
Chifukwa chake, ma probiotics samangowongolera thanzi la m'matumbo ndipo motero amawongolera zovuta zam'mimba, koma amakhala ndi zopindulitsa zambiri paumoyo wamunthu wonse. Mwachitsanzo, tikudziwa kuti ma probiotics amatha kuchepetsa mafuta m'thupi komanso kuthamanga kwa magazi, kuthandizira matenda a chingamu ndi khungu, kuteteza ku chimfine komanso kulimbitsa chitetezo cha mthupi. Zasonyezedwanso kuti ma probiotics ndi chikhalidwe cha zomera za m'mimba zingakhudze psyche yaumunthu.
Ma probiotics amakhudza psyche
Kapangidwe ka bakiteriya m'matumbo kumakhudza bwino thanzi lamalingaliro. Tizilombo toyambitsa matenda timayendetsa kadyedwe chifukwa mabakiteriya a m'matumbo athu amatiuza mobisa zomwe tiyenera kudya. Timaganiza kuti tili ndi chilakolako cha izi kapena izo. M'malo mwake, ndikulakalaka kwa mabakiteriya am'matumbo athu omwe timawawona ngati athu.
Inde, nthawi zambiri zomera za m'mimba - ngati zasokonezedwa - zimakhudzidwanso ndi chitukuko cha autism, ADHD, Alzheimer's, ndi kuvutika maganizo. Kafukufuku wosiyanasiyana m'zaka zaposachedwa wawonetsanso momwe chikhalidwe cha m'matumbo chimakhudzira kupsinjika kwamunthu. Potenga mabakiteriya ena a probiotic, mutha kuchepetsa zizindikiro zokhudzana ndi kupsinjika ndikuwonetsetsa kuti kupsinjika sikulinso kofunika kwambiri ndipo sikumadziwonetseranso mwamphamvu pazizindikiro zathupi.
Ma probiotics amathandizira kupsinjika kwa mayeso
Mu May 2016, kafukufuku wina wa ku Japan wokhudza ophunzira azachipatala omwe anali pafupi kulemba mayeso awo omaliza a zachipatala anasonyeza mmene mankhwala opangira ma probiotics amatha kuletsa kupsinjika maganizo.
Ophunzirawo adatenga ma probiotic supplement panthawi yokonzekera mayeso - ndipo adapeza kuti kupanikizika kwawo kwa mayeso ndi zizindikiro za nkhawa zomwe zimagwirizanitsidwa nazo zikhoza kuchepetsedwa kwambiri.
Mabakiteriya a Lactobacillus casei amatha kuchepetsa zizindikiro zambiri za kupsinjika maganizo, makamaka zomwe zimakhudza dongosolo la kugaya chakudya, akufotokoza wolemba kafukufuku Dr. Kouji Miyazaki, Mtsogoleri wa Food Research Department ya Yakult Central Institute, Tokyo, Japan.
Kafukufukuyu adasindikizidwa mu nyuzipepala yotchedwa Applied and Environmental Microbiology - magazini ya American Society for Microbiology.
Masabata asanu ndi atatu kuti mayeso ayambe, gulu lina la ophunzira (anthu 23) linatenga mankhwala oletsa tizilombo toyambitsa matenda (omwe munali L. casei). Gulu lachiwiri (ophunzira 24) adalandira placebo. Pakati pa mlungu uliwonse, wina ankawona momwe zizindikiro za kupsinjika maganizo za ophunzira zinasinthira. Kodi kupweteka kwa m'mimba ndi kusapeza bwino kunakula? Kodi nkhawa ndi mantha zidasintha?
Kuphatikiza apo, kuchuluka kwa mahomoni opsinjika kwa omwe akuphunzirawo (salivary cortisol) ndi zochita za majini 179 okhudzana ndi kupsinjika maganizo adawunikidwa. Zinapezeka kuti kutenga probiotic tsiku poyamba anatha kuchepetsa m`mimba mavuto ndi ululu m`mimba.
Ma probiotics amachepetsa kuchuluka kwa mahomoni opsinjika
Kuphatikiza apo, ophunzira omwe adalandira ma probiotic adamva kupsinjika pang'ono ndipo ma cortisol awo adatsika. Mlingo wa ntchito za majini opsinjika nawonso unasintha. Pagulu la placebo, izi zidakwera kwambiri pomwe mayeso akuyandikira. Mu gulu la ma probiotics, kumbali ina, linangowonjezeka pang'onopang'ono.
Pankhani ya mapangidwe a matumbo a m'mimba, ochita kafukufuku adatha kudziwa kuti chiwerengero cha mabakiteriya otchedwa Bacteroidetes mabakiteriya asanayesedwe adangowonjezeka kwambiri mu gulu la placebo. Banja ili la mabakiteriya am'matumbo limagwirizana mwachindunji ndi kupsinjika. Munthu akamapanikizika kwambiri, mabakiteriya ambiri a Bacteroidetes amakhala m'matumbo awo.
Mu gulu la probiotics, kumbali ina, zomera za m'mimba za ophunzira zimasonyeza kusiyana kwakukulu komanso kuchuluka kwa mabakiteriya a m'mimba.
Ma probiotics amachiritsa matumbo a ubongo
Osati kupsinjika kokha komanso nkhawa zimatha kuthandizidwa ndi ma probiotics chifukwa amawongolera zomwe zimatchedwa m'matumbo-ubongo axis kotero kuti kupsinjika ndi nkhawa zitha kuchepetsedwa. "Gut-brain axis" imatanthawuza kugwirizana pakati pa matumbo ndi ubongo. Izi zimachitika motere:
Mitsempha yambiri ya munthu imakhala m'matumbo - mpaka 70 peresenti malinga ndi magwero ena. Choncho munthu amalankhulanso otchedwa enteric mantha dongosolo kapena m'mimba ubongo. Ubongo wa m'mimba tsopano umagwirizana kwambiri ndi ubongo wamutu. Pali kukambirana kosalekeza pakati pa awiriwo - kusinthana kwa chidziwitso chomwe chimagwira ntchito mbali zonse ziwiri.
Izi zikutanthauza kuti ubongo ndi m'matumbo zimalamulira ndi kusonkhezera wina ndi mzake. Pankhani ya kusokonezeka kwa m'matumbo, ubongo ndi maganizo zimavutika - pankhani ya kupsinjika maganizo ndi chisangalalo cha maganizo, matumbo amavutika.
Momwe kupsinjika kumawonongera matumbo - komanso momwe matumbo amathandizira kuti azitha kupsinjika
Kusokonezeka m'matumbo kumatha kuyambitsidwa ndi matenda, maantibayotiki, komanso kupsinjika. Matendawa poyamba anasonyeza kusintha kosayenera kwa zomera za m'mimba.
Mabakiteriya omwe sali abwino kwa anthu amakhala ndi zotupa zomwe zimapangitsa kuti matumbo a m'matumbo achuluke kwambiri. The permeable intestinal mucosa ndi njira zotupa zosatha tsopano zimapangitsa kuti ubongo wa m'mimba utumize zizindikiro zofananira ku ubongo.
Zotsatira zake ndikuti mumachita mwamphamvu kwambiri kupsinjika, kukhala omvera kwambiri ndipo mwadzidzidzi mumakhala ndi nkhawa komanso kukhumudwa. Ma probiotics angathandize kusintha chitukukochi ndikulola kuti zomera za m'mimba zibwererenso.
Ma Probiotics amachepetsa nkhawa komanso kukhumudwa
M'zaka zapitazi za 15, maphunziro ambiri achitika pamutuwu - ndipo njira zomwe zingatheke zomwe ma probiotics amathandizira kuchepetsa nkhawa ndi kupsinjika maganizo pogwiritsa ntchito mphamvu zawo m'matumbo amadziwika kale:
- Ma Probiotic amapatsa mbewu zam'mimba ndi mabakiteriya athanzi ndipo motero amathandizira kukambirananso kogwirizana kwa m'matumbo ndi ubongo.
- Ma Probiotic amathamangitsa mabakiteriya oyambitsa kutupa komanso owononga m'matumbo omwe nthawi zambiri amatulutsa zinthu zapoizoni zomwe zimadziwika kuti zimayambitsa nkhawa komanso kukhumudwa.
- Ma probiotics amachepetsa kuchuluka kwa ma cytokines oyambitsa kutupa - ndipo kuchuluka kwa ma cytokine amadziwika kuti amagwirizana ndi kukhumudwa.
- Ma probiotics amalumikizana mwachindunji ndi dongosolo lapakati lamanjenje, zomwe zimapangitsa kusintha kwabwino kwa ma neurotransmitter muubongo. Ma neurotransmitters monga serotonin ndi dopamine tsopano ali ndi udindo wokhala ndi malingaliro abwino.
Tsopano, ma probiotics amatha kupangidwa ndi mitundu yosiyanasiyana ya mabakiteriya - ndipo si onse omwe amagwira ntchito mofanana polimbana ndi kupsinjika maganizo, kukhumudwa, nkhawa, ndi zina zamaganizo.
Ndi ma probiotics ati omwe amathandiza kupsinjika?
Mu phunziro lomwe lili pamwambali, mtundu wa bakiteriya L. casei unagwiritsidwa ntchito. Pali maphunziro ochulukirapo okhudza mphamvu yochepetsera kupsinjika kwa mitundu iwiri ya mabakiteriya Lactobacillus helveticus ndi Bifidobacterium longum. Onsewa amatha kukhala ndi anti-inflammatory effect pamatumbo a m'matumbo a mucosal.
L. helveticus ingatetezenso zomera za m'mimba kuti zisalowe ndi mabakiteriya owopsa. Ndipo mitundu yonse iwiriyi imachepetsa kutsekemera kwa khoma la m'mimba chifukwa cha zomwe zimatchedwa ntchito yotchinga.
Kuphatikizika kwa zotsatira zonsezi kumabweretsa kuchepa kwa kutupa kokhudzana ndi kupsinjika maganizo ndi kutupa kwa mitsempha m'matumbo a m'mimba ndiyeno kukonzanso zina zambiri za thanzi - zonse zakuthupi ndi zamaganizo.
Maphunziro a anti-stress ndi ma probiotics
Mu kafukufuku wapawiri, osayang'aniridwa ndi placebo, odzipereka odzipereka a 75 omwe akuvutika ndi zizindikiro za kupsinjika maganizo anatenga kuphatikiza kwa ma probiotics awiri otchulidwa (L. helveticus ndi B. longum) kapena mankhwala a placebo.
Pambuyo pa masabata atatu, mavuto okhudzana ndi kupsinjika maganizo (mseru, kupweteka kwa m'mimba) adachepa ndi 49 peresenti poyerekeza ndi gulu la placebo. Zizindikiro zamanjenje zamtima monga tachycardia zidakulanso mu gulu la probiotic.
Kafukufuku wina wazachipatala (Messaoudi et al., France) adawunikanso momwe ma probiotic awa amakhudzira kupsinjika, nkhawa, komanso kukhumudwa mwa anthu 55 opsinjika. Sikuti zizindikiro za thupi zokhudzana ndi kupsinjika maganizo zinasintha, komanso kuvutika maganizo, nkhawa, ndi kupsa mtima. Kuchepetsa kupsinjika kumatha kuwonetsedwanso mwachindunji kutengera milingo ya cortisol (mahomoni opsinjika), omwe adagwa kwambiri m'gulu la probiotic.
Ma probiotics amagwira ntchito yofunika kwambiri pakuchira kwamaganizidwe
Chosindikizidwa ndi Ait-Belgnaoui et al. anafufuza zotsatira za kuphatikizika kwa probiotic ku ubongo mwatsatanetsatane ndikutsimikizira kuti chikoka cha ma probiotics chikhoza kutsimikiziridwa momveka bwino pa msinkhu wa ubongo.9 Zinasonyezedwa apa kuti ma probiotics angapangitse kupsinjika maganizo kwachilendo kwa neuronal plasticity. Neuronal plasticity imalongosola kuthekera kwa maselo a mitsempha kuti asinthe ndikusintha. Kusintha kwamphamvu kwambiri komanso pafupipafupi kumawonedwa panthawi yakupsinjika, mkhalidwe womwe ma probiotics amawoneka kuti amatha kuwongoleranso.
Maphunziro onsewa amatsimikizira kuti ma probiotics apadera amatha kukhala ndi zotsatira zabwino kwambiri panjira yaubongo. Choncho, ma probiotics kapena zomera za m'mimba zathanzi zimagwira ntchito yofunika kwambiri pakuchira kusinthasintha kwa maganizo ndi kusokonezeka kwamaganizo kwa mitundu yonse.
Ma probiotics amateteza limbic system
Ma probiotics amawoneka kuti amachepetsa kwambiri mbali za ubongo zomwe zimagwirizanitsidwa ndi kupsinjika maganizo, nkhawa, ndi kupsinjika maganizo, kotero angathandize kuti mahomoni opsinjika maganizo asatulutsidwe.
Zawonedwanso kuti ma probiotics amatha kuchepetsa apoptosis yokhudzana ndi kupsinjika (ma cell kufa kwadongosolo) mu limbic system, dera laubongo komwe mwachitsanzo Zomverera zimasinthidwa.
Choncho ma probiotics amatchulidwa kale ndi asayansi ena otchedwa psychobiotics (Dinan et al.) - pogwiritsa ntchito mawu akuti "psychotropic", omwe amatanthauza chinthu chomwe chimakhudza psyche.
