Soya Kwa Prostate

Kumwa soya pafupipafupi kumatha kupewetsa zovuta za prostate. Zogulitsa za soya zingathandizenso kusintha kwabwino kapena koyipa kwa prostate.

Soya muzakudya - ndipo kuchuluka kwa khansa ya prostate kumachepa

Soya wakhala wotchuka kwambiri m'zaka zaposachedwapa. Osati kale kwambiri, zogulitsa za soya zimangopezeka m'masitolo a organic komanso azaumoyo. Mkaka wa soya ndi tofu tsopano zikupezeka pafupifupi m'masitolo akuluakulu - osachepera chifukwa amakhulupirira kuti Asiya ar

Chifukwa anthu akumadera aku Asia samangokhala ndi khansa ya m'mawere yochepa komanso khansa ya prostate yochepa kusiyana ndi anthu akumadzulo - koma ngati akukhala m'mayiko awo. Anthu aku Asia akasamukira Kumadzulo, amakhala ndi mwayi wopezeka ndi khansa ya prostate kuposa anzawo omwe amakhala kwawo.

Anthu a ku Asia omwe amadya zakudya zakumadzulo amakhala ndi kansa ya prostate

Kumbali ina, akuti mayiko ambiri a ku Asia alibe njira zodziwira matenda monga momwe zimakhalira kumayiko a Kumadzulo ndipo anthu ambiri omwe ali ndi khansa ya prostate sanapezeke poyambirira. Komabe, chimenecho chokha sindicho chifukwa. Zakudya zimathandizanso kuti pakhale chiopsezo cha khansa - ndipo izi ndizosiyana kwambiri kumadzulo kuposa ku Asia. Amuna aku Asia atangosiya kudya mankhwala a soya m'nyumba yawo yatsopano (Europe kapena USA), amasiya kumwa tiyi wobiriwira, ndipo mwina amadya masamba ochepa, chiopsezo cha khansa ya prostate chikuwonjezeka, chomwe chikuwonekera makamaka m'badwo wachiwiri.

Choncho, mu 2012, ofufuza mu Chinese Journal of Cancer analemba kuti:

"Kugwiritsidwa ntchito kwa soya kumakhala kofala kwambiri ku Asia ndipo kumalumikizidwa ndi 25 mpaka 30 peresenti yochepetsera chiopsezo cha khansa ya prostate."
Chiwopsezo chocheperako chimakhudzana makamaka ndi zinthu zopanda chotupitsa za soya - malinga ndi Spitznagel et al. mu 2009 meta-analysis, yomwe ili yosangalatsa makamaka chifukwa chofala chonena kuti zofufumitsa za soya zimakhala zathanzi kuposa zopanda chotupitsa.

Zopangidwa ndi soya zofufumitsa komanso zopanda chotupitsa

Zogulitsa za soya zopanda chofufumitsa ndi monga B. mkaka wa soya ndi tofu. Komabe, pakali pano palinso tofu wothira, ena amakoma kwambiri (mwachitsanzo, soyananda kuchokera ku Soyana). Zitsanzo za mankhwala a soya wothira ndi monga msuzi wa soya, miso, natto, ndi tempeh.

Kodi soya amagwira ntchito kwa anthu aku Asia okha?

Ndiye akuti kachiwiri kuti zoletsa zotsatira za soya zingagwire ntchito kwa amuna aku Asia, koma osati amuna ochokera kumadera akumadzulo. Ngati muyang'ana pa maphunziro, komabe, ndi mwachitsanzo, pamene amuna a ku Ulaya ankachitidwa, zikuwonekeratu kuti kuchuluka kwa soya komwe kuli kothandiza kwa amuna a ku Asia sikunagwiritsidwe ntchito pano, koma otsika kwambiri - chifukwa omwe amaganiziridwa. kukhala odya kwambiri soya ku Europe angaonedwe kuti soya wocheperako ku Asia - Count odya.

Ngakhale mu maphunziro aku Asia zosakaniza za soya (monga genistein) zimaperekedwa ndikudyedwa mu milingo ya mg, mu maphunziro a ku Europe ndi kuchuluka kwa µg kokha - zomveka kuti palibe chomwe chingawonetsedwe apa.

Ndipo ndizomveka kuti m'maphunziro omwe amamwa soya kwambiri, zotsatira zake zimatha kuwonedwa - ngakhale kwa omwe si Asiya, mwachitsanzo B. mu kafukufuku wakale ndi anthu aku US ndi Canada (Adventist Health Study). Pakafukufukuyu, chiopsezo cha khansa ya prostate chimachepetsedwa mpaka 70 peresenti ngati mkaka wa soya umamwa nthawi zonse (kawirikawiri patsiku).

Kodi Asiya Amadya Soya Wochuluka Bwanji?

Popeza amanenedwa mobwerezabwereza kuti anthu aku Asia samadya soya wochuluka, kuchuluka kwa zinthu za soya m'maiko aku Asia adayesedwa ndipo adatsimikiza kuti 6 - 11 g soya mapuloteni kapena 25 mpaka 50 mg soya isoflavones amadyedwa kumeneko. patsiku. Apa mupeza tebulo lomveka bwino lomwe lili ndi isoflavone pazinthu zosiyanasiyana za soya.

Chitsanzo: 40 mg soya isoflavones amapezeka mwachitsanzo B. mu 100 g tofu wokhazikika ndi 200 ml mkaka wa soya.

Zomwe zimagwiritsidwa ntchito mu soya - ma isoflavones

Zimaganiziridwa kuti ndi ma isoflavones mu soya makamaka omwe amatsogolera ku zotsatira zopewera khansa zomwe zatchulidwa. Isoflavones (yomwe imatchedwanso isoflavonoids) ndi zinthu zamtundu wachiwiri kuchokera ku gulu la flavonoids, lomwe limaphatikizapo anthocyanins - mtundu wamtundu wamtundu wamtundu wakuda wa mabulosi akuda, zipatso za aronia, mphesa zabuluu, kapena kabichi wofiira.

Flavonoids akhala akudziwika kale chifukwa cha antioxidant, anti-inflammatory, vascular-protecting, ndi anti-cancer zotsatira.

Ma isoflavones amapezeka mulingo woyenera osati mu soya komanso mu nyemba zina (napiye) ndi red clover. Ma isoflavone a soya amatchedwa u. Daidzin (kapena Daidzein) ndi Genistein.

Ma Isoflavones ali ndi mphamvu yofooka ya estrogen (nthawi 100 mpaka 1000 yocheperako kuposa ma estrogens am'mimba kapena ngakhale amankhwala) motero amatchedwanso ma phytoestrogens, kutanthauza kuti ma estrogens a chomera.

Ma isoflavones amatha kukhudza kuchuluka kwa mahomoni ndipo amalumikizidwa ndi chiwopsezo chochepa cha khansa yodalira mahomoni - khansa ya m'mawere, khansa ya m'mawere, khansa ya prostate.

Ma Isoflavones: othandizira kupewa khansa ndi chithandizo

Kale mu 2003, nkhani ya Cancer Investigations Soy Isoflavones ndi Cancer Prevention idawerenga kuti maphunziro a in vitro komanso maphunziro a vivo (zofufuza pa nyama ndi anthu) adawonetsa kuti genistein - isoflavone yayikulu mu soya - njira yodalirika yopewera kapena kuchiza khansa. .

Amuna omwe ali ndi soya muzakudya zawo amakhala ndi milingo ya isoflavone yapamwamba kuposa omwe sakonda soya. Makamaka milingo ya isoflavone yokwera kwambiri imatha kupezeka mu prostate popeza zinthuzo zimawunjikana pamenepo.

Komano, m'magazi, ma isoflavones amangozungulira kwakanthawi kochepa, zomwe zikutanthauza kuti ma isoflavones amasamutsidwa mwachangu kupita komwe atha kukhala othandiza, pomwe zotsatira zosafunika pa ziwalo zina sizingachitikenso.

Zotsatira za isoflavones

Zotsatirazi ndi njira zogwirira ntchito zimachokera ku isoflavones ya soya:

• Ma Isoflavones ochokera ku soya ali ndi antioxidant wamphamvu - monga momwe mumazolowera kuchokera ku flavonoids: Amachotsa mpweya wabwino womwe ungakhale ndi zotsatira zovulaza ndipo ukhoza kukhala ndi zotsatira zolimbikitsa khansa komanso zoyambitsa kutupa.
• Ma Isoflavones amakhudzanso kuchuluka kwa mahomoni. Komabe, samatsitsa mlingo wa testosterone, monga momwe amawopedwa nthawi zambiri, koma amapewa mwachitsanzo B. Benign Prostatic hyperplasia (BPH, kukulitsa kwa prostate) kupyolera mu zotsatira zawo za estrogen, zomwe zingathe kubwezera zotsatira za testosterone. Amalepheretsanso kutembenuka kwa testosterone kukhala DHT (dihydrotestosterone). DHT ndi njira yogwira ntchito ya testosterone yomwe ingayambitse kukula kwa maselo mu prostate ndipo motero imathandizira ku BPH.
• Ma soy isoflavones amatha kuchita ngati ma estrogens mukusowa kwa estrogen motero amachepetsa zotsatira za kuperewera kofananira. Komabe, amathanso kuchepetsa mphamvu ya estrojeni yamphamvu pakachitika kuchuluka kwa estrojeni, chifukwa amamangiriza ku zolandilira za estrogen m'malo mwa ma estrogens amkati, komwe amakhala ngati estrogen koma amakhala ofooka nthawi zambiri kuposa "weniweni. ” estrogen.
• Mu Marichi 2014, ofufuza a ku Yunivesite ya Chicago, Illinois adasindikiza ndemanga yofotokoza momwe soya isoflavones ingapewere ndikumenyana ndi khansa ya prostate. Zimaphatikizapo kuwerenga kuti soya isoflavones amalepheretsa kukula kwa khansa ya prostate mu kuyesa kwa nyama ndi maselo chifukwa amalepheretsa maselo a khansa kukula ndikulimbikitsa apoptosis (pulogalamu yodzipha khansa).
• Amafotokozedwanso kuti zinthu za soya zimakhalanso ndi zotsatira zabwino chifukwa cha kuthekera kwawo kulimbikitsa kukonza kwa DNA komanso kuletsa angiogenesis (kupangidwa kwa mitsempha yatsopano yamagazi yomwe imadyetsa zotupa) ndi mapangidwe a metastasis.
• Soy isoflavones amathanso kutsagana ndi ma radiation ndi chemotherapy. Ayenera kupititsa patsogolo zotsatira zomwe akufunidwa ndi radiotherapy ndi chemotherapy panthawi imodzimodziyo kuchepetsa zotsatira zake.

Mphamvu ya soya pamilingo ya PSA

Mtengo wofunikira wamagazi womwe umawunikidwa nthawi zonse mu khansa ya prostate ndi mtengo wa PSA. PSA ndi chidule cha Prostate Specific Antigen. Ndi puloteni yopangidwa ndi prostate ndipo imasunga madzi a umuna ndi umuna. PSA imalowanso m'magazi, pomwe imagwiritsidwa ntchito ngati chizindikiro cha thanzi la prostate. Ngati mtengo wa PSA ukuwonjezeka mwadzidzidzi komanso mosalekeza, izi zitha kuwonetsa khansa ya prostate kapena benign prostatic hyperplasia.

Komabe, munthu ayenera kusamala pofotokoza mfundo zoyendetsera PSA, chifukwa choyamba mtengo wa PSA ukhoza kukhudzidwa ndi zinthu zambiri, chachiwiri, ukhoza kusiyana kwambiri kuchokera kwa munthu kupita kwa munthu ngakhale mwa amuna athanzi ndipo chachitatu chitukuko cha PSA ndi. motsimikiza kuposa kuwerenga kamodzi.

Njirayi ili motere: Kuchokera ku PSA ya 4 ng / ml, imafufuzidwa nthawi ndi nthawi. Ngati iwuka, pakufunika kufotokozera. Komabe, PSA yochepera 4 ng/ml sichiletsa khansa ya prostate. Chifukwa chake, mtengo wa PSA siwoyenera kugwiritsidwa ntchito ngati chida chokhacho chodziwira matenda a prostate. Komabe, kupambana kwa BPH ndi chithandizo cha khansa ya prostate kumayesedwa nthawi zonse pogwiritsa ntchito mtengo wa PSA. Ngati mtengowo ukutsika kapena ukhoza kukhazikika, dokotala ndi wodwala amamasuka.

Genistein amachepetsa PSA

Mu 2011, kafukufuku adawonekera mu Southern Medical Journal yomwe inapempha amuna a 10 kuti adye malonda a soya kwa zaka ziwiri. Anapitiriza kusonyeza kukwera kwa PSA pambuyo pa prostatectomy (kuchotsedwa kwa prostate) ndi chithandizo cha radiation. Pambuyo pa maphunzirowa, milingo ya PSA mu theka la omwe adatenga nawo mbali idagwa chifukwa cha zinthu za soya.

Mu phunziro lachipatala lachindunji, loyendetsedwa ndi placebo, komanso lachiwiri lakhungu lachiwiri, asayansi ochokera ku Oslo University Hospital / Norway anapatsa ophunzira awo (omwe onse anali ndi khansa ya prostate) 30 mg ya genistein kapena kukonzekera kwa placebo tsiku ndi tsiku masabata asanakwane. opaleshoni. Panali anthu 23 m'gulu la genistein ndi 24 m'gulu la placebo.

Mtengo wa PSA unatsika ndi 7.8 peresenti mu gulu la genistein poyerekeza ndi 4.4 peresenti yokha mu gulu la placebo. Komabe, ngakhale mtengo wa PSA mu gulu la placebo unangotsika mu minofu ya chotupa koma osati mu minofu yathanzi, unachepetsedwa mu gulu la genistein ponse mu minofu ya chotupa ndi minofu yathanzi.

Panthaŵi imodzimodziyo, amuna a genistein ankasangalala ndi milingo yotsika ya kolesteroloni, yomwe siinaoneke mwa amuna a placebo. Zinalinso zofunika kuti genistein sanakhudze kuchuluka kwa timadzi tating'onoting'ono kapenanso kuchuluka kwa mahomoni a chithokomiro.

Kodi genistein ndi yochuluka bwanji muzinthu za soya?

Popeza 30 mg ya genistein imatha kulowetsedwa mosavuta ndi zakudya zomwe zili ndi soya, ofufuza omwe akukhudzidwa amalimbikitsa kutero - osati chifukwa cha zotsatira zabwino pamagulu a kolesterolini omwe angathe kuyembekezera nthawi yomweyo komanso kusowa kwa zotsatira zosafunika pa hormone. bwino.

Ma Isoflavones amayimitsa milingo ya PSA, yomwe ikupitilizabe kukwera ngakhale chithandizo chamankhwala chodziwika bwino
Kafukufuku adasindikizidwa mu Nutrition and Cancer nthawi yapitayo (2003) momwe odwala 41 omwe ali ndi khansa ya prostate adatenga nawo gawo. Iwo adagawidwa m'magulu atatu:

Gulu 1 lomwe lili ndi khansa ya prostate yomwe yangopezeka kumene komanso yosachiritsika komanso kukwera kwa PSA.
Gulu 2 lokhala ndi khansa ya prostate, yomwe, ngakhale chithandizo choyambirira (radiation, etc.), idapangitsa kuti PSA ichuluke nthawi zonse.
Gulu 3 lokhala ndi khansa ya prostate, zomwe zidapangitsa kuti PSA ichuluke nthawi zonse ngakhale atalandira chithandizo chamankhwala.
Odwala onse analandira 100 mg isoflavones kawiri pa tsiku kwa miyezi 3-6. Ngakhale kuti PSA ya otenga nawo mbali sinathe kuchepetsedwa, idayimitsidwa ndikukhazikika mu 83 peresenti ya odwala omwe ali mu Gulu 2, zomwe zinali zopambana kwambiri chifukwa milingo ya PSA idapitilirabe kukwera mosasamala kanthu za zoyeserera zachipatala.

Mu gulu la 3, zotsatirazi zinatheka mu 35 peresenti ya odwala. Mu phunziro ili, nawonso, chomera chochokera ku soya sichinakhudze milingo ya testosterone ya otenga nawo gawo pang'ono - ngakhale ndi mlingo waukulu kwambiri wa isoflavone kwa nthawi yayitali.

Ofufuzawo adawona kuti ma isoflavones a soya atha kupereka phindu lalikulu kwa odwala khansa ya prostate - ngakhale chithandizo chanthawi zonse chikalephera.

Mkaka wa soya umachepetsa kukwera kwakukulu kwa PSA

Pakafukufuku wa University of Florida kuchokera ku 2008, odwala 20 a khansa ya prostate amamwa 250 ml ya mkaka wa soya katatu patsiku kwa chaka chimodzi (zofanana ndi 141 mg ya isoflavones molingana ndi kapangidwe kake). Odwala onse anali atalandira kale chithandizo - 11 anali atachotsedwa prostate ndipo 9 adalandira chithandizo cha radiotherapy.

Phunziroli lisanachitike, ngakhale njira zochiritsira zam'mbuyomu, milingo ya PSA idakwera pafupifupi 56 peresenti pachaka. Mothandizidwa ndi mkaka wa soya, mtengowo udakwera pafupifupi 20 peresenti.

Kafukufuku wotsatirawu akuwonetsa kuti zinthu za soya zitha kutengedwanso bwino limodzi ndi mankhwala wamba:

Ma isoflavones amathandizira chithandizo cha radiation ndikuchepetsa zotsatira zake

Mu 2010, ofufuza adafalitsa kafukufuku mu nyuzipepala ya Nutrition and Cancer yofufuza za ubwino wa soya isoflavone kudya kwa odwala omwe akudwala khansa ya prostate.

Popeza soya isoflavones sikuti amangokhudza prostate kudzera muzinthu zawo zokhala ngati mahomoni komanso amakhala ndi antioxidant komanso anti-inflammatory properties, tinkayembekeza kuti isoflavones ingachepetse zotsatira za radiotherapy.

Odwala 42 adalandira 200 mg isoflavones kapena kukonzekera placebo tsiku lililonse kwa miyezi 6. Zinapezeka kuti soya isoflavones amatha kuchepetsa zotsatira zambiri za mankhwala opatsirana pogwiritsa ntchito ma radiation, monga matenda a m'mimba, kusokonezeka kwa kugonana (kusowa mphamvu), ndi mavuto a mkodzo (kulephera kwa mkodzo). Chifukwa gulu la placebo linavutika kwambiri ndi zizindikirozi kuposa gulu la soya.

Soy isoflavones angagwiritsidwenso ntchito kuwonjezera pa mankhwala ochiritsira ndipo motere amachititsa kuti mankhwalawa azikhala osangalatsa.

Soya ndi tiyi wobiriwira: Kuphatikiza kwanzeru

Kafukufuku wa Oregon State University adasindikizidwa chaka chomwecho. Zinadziwika kuti zingakhale zomveka kuphatikiza zinthu za soya muzakudya pamodzi ndi tiyi wobiriwira. Chifukwa kuphatikiza kwa onse awiri kunatha - osachepera makoswe omwe akugwira nawo ntchito - kubwezeretsa kukulitsa kwa prostate ndikuteteza ku khansa ya prostate kuposa soya kapena tiyi wobiriwira yekha.

Apanso, ofufuzawo akukayikira kuti zakudya zonse ziwirizi zimapangitsa kuti pakhale thanzi labwino, makamaka chifukwa cha antioxidant ndi anti-inflammatory effect. Chifukwa khansa ya prostate ndi kukula kwa prostate kumagwirizana kwambiri ndi kutupa kosatha.

Mosiyana ndi izi, kuphatikiza kwa lycopene ndi genistein (phwetekere ndi soya) sizikuwonekanso kuti zikugwira ntchito. Apa, lycopene imagwira ntchito bwino yokha kuposa kuphatikiza ndi soya:

Lycopene imakhazikitsa milingo ya PSA bwino kuposa soya

Kafukufuku wa in vitro adawonetsa kuti lycopene - chomera chachiwiri kuchokera ku mwachitsanzo B. tomato - ndi genistein wochokera ku soya adatha kuyambitsa apoptosis (pulogalamu yodzipha khansa ya khansa) ndikuletsa kukula kwa maselo a khansa - mu khansa ya prostate yomwe imakhudzidwa ndi mahomoni ndi mahomoni. ma cell.

Ofufuza a Wayne State University ku Detroit adachita kafukufuku wina wa chipatala mu 2007 kuti awone ngati lycopene kuchokera ku tomato ikhoza kupititsa patsogolo phindu la PSA. zotsatira za soya.

Ophunzirawo anali amuna a 70 omwe amachulukitsa PSA mosalekeza kapena mlingo wocheperako wa PSA wa 10 ng / ml. Amuna onse anali atalandira kale chithandizo chapafupi kapena anali kulandira chithandizo chamankhwala.

Analandira kapisozi imodzi ya tomato (15 mg lycopene) kawiri pa tsiku kapena kapisozi yemweyo kuphatikiza kapisozi imodzi ya 40 mg soya isoflavones kawiri pa tsiku kwa miyezi isanu ndi umodzi.

M'magulu onse awiriwa panali zotheka kuchepetsa ma PSA. Komabe, amuna 22 mwa amuna 33 mugulu lophatikizana anali ndi PSA yokhazikika, zomwe ndi zotsatira zabwino. Komabe, zotsatira zake mu gulu la lycopene zinali zabwinoko. Apa mtengo wa PSA udakhazikika pafupifupi mwa onse omwe atenga nawo mbali.

Zodabwitsa ndizakuti, 15 mg wa lycopene akhoza kulowetsedwa mosavuta kudzera muzakudya. Sikoyenera kutenga makapisozi a lycopene. 500 g tomato watsopano, 350 g chivwende, 200 ml madzi a phwetekere, kapena msuzi wa phwetekere wopangidwa kuchokera ku 50 g phala la phwetekere ndizokwanira.

Soya kwa khansa ya prostate
Zomwe zili pamwambazi ndizoti mungathe kuphatikizapo zakudya zopangidwa kuchokera ku soya (tofu, tempeh, mkaka wa soya, etc.) muzakudya zanu nthawi iliyonse komanso ndi chikumbumtima choyera - kaya muli ndi khansa ya prostate kapena ayi. Choyipa kwambiri chomwe chingachitike ndikuti simukuwona zotsatira zake - zabwino kapena zoyipa.

Monga tawonetsera, pali maphunziro ambiri omwe amatsimikiziranso kuti kukonzekera kwa soya isoflavone kuli ndi zotsatira zothandiza pa khansa ya prostate. Koma palinso maphunziro omwe amasonyeza kuti palibe zotsatira pano.

Zotsatira zoyipa zapezeka m'maphunziro omwe amagwiritsa ntchito kuchuluka kwambiri kwa isoflavone komwe sikungatheke ndi zakudya zomwe zili ndi soya. Zakudya zowonjezera zakudya zokhala ndi soya isoflavones zakutali ziyenera kupewedwa kapena kusankhidwa mosamala (pamlingo wochepa).

Zakudya za soya zimakhala ndi njira yabwino yodzitetezera ngati mumazizolowera kuyambira muli mwana monga gawo lazakudya zochokera ku mbewu zokhala ndi zinthu zofunika kwambiri (zowona ATANGOKHALA khanda) ndikuzidya mochulukira m'moyo wanu wonse (monga 100 g tofu ndi/ kapena 200 ml chakumwa cha soya patsiku).

Chakudya chochokera ku mbewu ndicho chisankho chabwino kwambiri pazifukwa zinanso, popeza mafuta anyama ndi mkaka wa m'mawere adalumikizidwa ndi chiopsezo chowonjezeka cha khansa ya prostate. Ngati mumasamaliranso kupezeka kwa vitamini D, kudya omega-3 fatty acids okwanira, ndipo nthawi zambiri mumadya masamba a kabichi okhala ndi turmeric, mutha kuyembekezera zabwino zopewera khansa ya prostate kuchokera muzakudya zanu.