Allison Turner
Chikwata chepasi rose chevaongorori chingave chakawana budiriro mukurapa multiple sclerosis. Mumuenzaniso wemhuka, kushandiswa kwemiti yemiti (cyclotides) yakaunza kutanga, kubudirira kukuru. Kumashure.
Mune ramangwana, chirwere che autoimmune multiple sclerosis chicharapika. Vatsvagiri veMEDUni Vienna nevamwe vavo vekutsvagisa pasi rose (Australia, Germany, neSweden) vane chokwadi neizvi.
Kusvika parizvino, multiple sclerosis haigone kurapwa, asi inogona kurapwa. Chirwere ichi chinogona kurapwa nemishonga yakadai secortisone - asi nemigumisiro isingafadzi. Chikwata chetsvakiridzo chepasi rose chinotungamirwa nemukuru wekutsvagisa Christian Gruber chatora rimwe danho rekurwisa MS. Ivo vanofungidzira kuti chirimwa polypeptides (cyclotides) inorapa MS.
Chirwere chinonyengera chemultiple sclerosis
Dziviriro yezvirwere zvemuviri inofanira kudzivirira muviri wayo pachawo kubva kune vanoupinda kana kurwisa kuzvimba. Hazvina kudaro ne multiple sclerosis (MS) - chirwere che autoimmune chepakati penheyo system. Muviri unotungamira kuzvidzivirira kwawo pachezvawo. Nekuda kweizvozvo, iyo insulating layers yetsinga dzayo (myelin kana marrow layer) muuropi nemuzongoza zvinopisa. Stimulus kutapurirana kunoitwa zvakanyanya kuoma kana kuita zvisingaite kana yakaputswa zvachose.
Mune varwere veMS, izvi zvinozviratidza mukuoma mitezo yemhasuru dzechiso, kusagadzikana kwekutaura, asiwo weti incontinence. Chirwere ichi chinofambira mberi muzvikamu, izvo zvinoratidzwa mune zvitsva kana kudzokorora kuputika kwezviratidzo zvinozivikanwa.
Vitamin D uye multiple sclerosis
Maitiro ekuzvimba uye zvikonzero kusvika parizvino zvakangojekeswa zvishoma. Kushaikwa kwevhitamini D kunofungidzirwa, semuenzaniso. Mishonga yakadai secortisone inorwisa-kuzvimba uye inogona kushandiswa kurapa acute flare-ups. Zviratidzo zvinopera pashure penguva pfupi. Chainyanya kuipa ndechekuti vanogona kungopihwa netsinga uye kuva nemhedzisiro yakaipa.
Nematomatisi kubudirira
Cyclotides mapeptides (mapuroteni madiki) anowanikwa kubva kuzvirimwa zvakasiyana senge nightshades (matomatisi), uswa uye zvidyarwa zvekofi uye anogona kumisa maitiro ekuzvimba mu immune system. Vatsvakurudzi vakaona kuti vanodzvinyirira kusunungurwa kwemutumwa interleukin-2 uye kudzivirira kupatsanurwa kwesero reT masero ("muurayi" kana "mubatsiri" masero).
Masayendisiti kuMedUni Vienna, pamwe nevamwe vavo vekune dzimwe nyika vekutsvagisa, vakashandisa ruzivo nezvezvinomera uye vakaita chidzidzo chembeva. "Mumuenzaniso wemhuka weMS, kuitika kwezviratidzo kwakaderedzwa zvakanyanya nemuromo wekutonga cyclotides," anodaro mutungamiri weboka rekutsvakurudza Christian Gruber.
Vakakwanisa kuratidza kuti kunwa kamwe nemuromo kwechirimwa peptide kunogona kumisa MS padanho rekutanga. Nguva pakati pekurwiswa yakava yakareba uye foci yekuzvimba zvishoma. Mhuka dzacho dzakaratidza kuti hadzina kuipa.
Vakaburitsa zvakabuda muongororo yavo muPNAS (Proceedings of the National Academy of Science of the United States of America).
Kuwanikwa kwesainzi kunopa tariro kune varwere veMS
Vatsvakurudzi vanofungidzira kuti migumisiro yekudzidza kwavo inogona kuendeswa kuvanhu.
“Pakangotanga kushaikwa kwetsinga dzetsinga uye shanduko yekutanga ine chekuita nechirwere mukati mehurongwa hwetsinga hunoonekwa muMRI scan (Cherechedza: Magnetic Resonance Imaging), mushonga unogona kupihwa semushonga wekurapa. Saka zvinogona kuve kuti nguva iri pakati pekupisa-ups yakawedzerwa kana kuti kubuda kwechirwere kunogona kudzivirirwa, "masayendisiti akadaro aine tariro.
Nekuda kwekubudirira kwekudzidza mbeva, MedUni Vienna, pamwe neFreiburg University Hospital, vakanyorera patents yechirimwa peptide munyika dzakati wandei uye vakatanga kambani yeCyclone. Chinangwa ndechekugadzira mushonga unoshanda nemuromo unogonesa varwere veMS kutungamira hupenyu "hwakajairika". Zvinoenderana nevatsvagiri, chikamu chekutanga chekiriniki chidzidzo chinogona kutanga mukupera kwa2018.
