John Myers
Abasetyhini abafunyaniswa benomhlaza wamabele bahlala belunyukiswa ngeemveliso zesoya. Kuthiwa isoyi iya kunciphisa impumelelo yonyango lwe-anti-estrogen. Iziphumo zophando olutsha ngoku ziye zazisa into emangalisayo ekukhanyeni: amajoni omzimba wabathengi besoya bexesha elide anokuhlasela umhlaza wamabele ngcono kakhulu. Kwaye nokuba kwenzeka umhlaza wesifuba, abathandi be-soy bakhuselekile ngakumbi ekuphindaphindeni kunabasetyhini abangazange badle i-soy, ekungekho mntu wayekholelwa kuyo.
Isoya - ukusuka kwiimbotyi ezingummangaliso ukuya kwinkunkuma eyingozi
I-Soy ibe yi-doormat yokwenyani mva nje. Awunakuphinda ushiye iinwele ezilungileyo kwimbotyi yangaphambili yommangaliso. Kuyalunyukiswa ukuba umdumba awuyonto ngaphandle kwenkunkuma enetyhefu eyingozi kakhulu.
Kuyinyani ukuba i-soy ye-GM ayiyona i-yellow yeqanda kwaye ngokuqinisekileyo kufuneka uyeke kwi-mono-nutrition nayo. Kodwa akubuhlungu ukwahlula kancinane.
Kuba kukho neendaba ezimnandi malunga nesoya. Kwaye ukuba ukhetha isoya yomgangatho we-organic, mhlawumbi ukusuka kwimveliso yengingqi (umz. isiJamani), wamkelekile ukuba wenze njalo ngamaxesha athile. Akunyanzelekanga ukuba ibe sisixa esikhulu.
Ukusetyenziswa kwesoya rhoqo – umz. intwana encinci kaninzi evekini – ingaba neenzuzo zempilo ezinomdla kakhulu, ngakumbi ukuba ubuyithanda isoya ukusukela ubuncinci.
I-Soy yezigulane zomhlaza webele
Uphononongo olutsha lwesoya lwanikezelwa kwintlanganiso yonyaka ye-American Association for Cancer Research (AACR) - kwaye hayi, ayizange ixhaswe yi-soy industry.
Uphononongo luqhutywe liqela lophando elikhokelwa nguDkt. Leena Hilakivi-Clarke, uprofesa we-oncology kwi-Georgetown Lombardi Comprehensive Cancer Centre.
Unjingalwazi u-Hilakivi-Clarke ubhengeze ukuba uneendaba kubo bonke abo basetyhini bebesoloko bebandakanya iimveliso zesoya ekutyeni kwabo iminyaka emininzi.
Ngokutsho kukanjingalwazi, akuyomfuneko kwaphela ukuyeka ukutya iimveliso zesoya xa ufunyaniswa ukuba unomhlaza webele. Ude acebise kakhulu ngokuchasene nokuphepha iimveliso zesoya kule meko. Abaguli abanomhlaza wamabele ngakumbi banokuzuza kakhulu kwiimbotyi zesoya.
I-Soy hysteria isekelwe - ubuncinane inxalenye - ekutolikweni okungalunganga kwezesayensi
Ukuza kuthi ga ngoku bekukholelwa ukuba i-soy kwaye ngakumbi i-genistein equlethwe (i-isoflavone) inokukhuthaza kwaye ikhuthaze ukukhula kweeseli zomhlaza webele. Kwakhona kwakukholelwa ukuba i-soy yaphazamisa unyango lwe-anti-estrogen oluqhelekileyo olusetyenziswa kumhlaza webele.
Ngenxa yoko, ii-oncologists ziye zabongoza abaguli babo abanomhlaza wamabele ukuba bayeke ukutya iimveliso zesoya.
Nangona kunjalo, le mbono yayisekelwe kuvavanyo lweempuku, kwaye ngokungafaniyo nabantu (okanye iimpuku), iimpuku azinayo into ebizwa ngokuba yi-cytotoxic T cells, uhlobo lweseli oluye lwe-immune cells.
Iiseli ze-Cytotoxic T, nangona kunjalo, liqela leseli elikwazi ukulwa nomhlaza wamabele.
I-Soy genistein inceda ukulwa nomhlaza
Kuphononongo lwangaphambili, iqela lophando likaProf. Hilakivi-Clarke libonise ukuba iimpuku ezinikwe i-genistein kubo bonke ubomi bazo zasabela ngcono kakhulu kunyango lwe-anti-estrogen kunezilwanyana ezilawulayo ezingazange ziyifumane i-genistein.
Kwakhona, iqela leGenistein lalinomngcipheko ophantsi wokuphindaphinda umhlaza.
Ngokuzenzekelayo, i-genistein ayifumaneki kuphela kwiimbotyi zesoya (kodwa apha kwidosi ephezulu), kodwa nakwiimbotyi ezibanzi kunye nezinye iimbotyi, kwaye kwiindawo ezisezantsi nakwiziqhamo nemifuno.
Kukho inani leendlela ezaziwayo apho i-genistein inokunciphisa umngcipheko womhlaza. Nangona kunjalo, i-genistein inokuphinda isebenze i-receptors ye-estrogen yabantu, izenza i-molecule ye-estrogen, kwaye ivumele iiseli zomhlaza ezikhoyo ukuba zikhule.
Kuphononongo lwangoku, abaphandi babejonge iinkcazo malunga nokuba iziphumo zabo zangaphambili bezinokuthi zenzeke njani, ngokutsho kwe-genistein yayichasene nomhlaza kwaye ayizange ikhulise ukukhula komhlaza.
Iqela likaHilakivi emva koko lafumana oku kulandelayo:
Isoya yomeleza iiseli ezihlasela umhlaza
Wathi T-iiseli ukuhlasela iiseli ithumba. Noko ke, ezinye iiseli zokhuselo lomzimba zinokuwenza angasebenzi obu buchule beeseli T kwakhona. Ukuba oku kwenzeka, i-tumor ingaqhubeka ikhula - ingalawulwa ngokupheleleyo.
Nangona kunjalo, ukuba ubusitya iimveliso zesoya ukusukela usemncinci (okt nangaphambi kokufikisa), i-genistein ibonakala iqinisekisa ukuba iiseli ze-T ziyaqaphela kwaye zilwe namathumba ngempumelelo. Zonke iinzame zomhlaza zokuzifihla ekuhlaselweni kwe-immune system ziyasilela kule meko.
I-Genistein ke ngoko inokucwangcisa amajoni omzimba ukuze akwazi ukulwa nomhlaza ngokufanelekileyo xa kubaluleke kakhulu.
Into ephuma kwimbotyi yesoya ivuselela iiseli ze-T ezilwa nethumba kwaye kwangaxeshanye icinezele ezo seli eziza kukhokelela ekuthinteleni iiseli ze-T-ekuthi, ngokutsho kukaNjingalwazi uHilakivi, uya kuchaza ukuba kutheni ukusetyenziswa kwesoya ixesha elide (okt. ukusukela ebuntwaneni nakwishumi elivisayo) ingaba oku kunokunciphisa umngcipheko womhlaza wamabele.
Kungcono ukutya isoya usemncinci!
Nangona kunjalo, kubalulekile ukuba i-genistein isetyenziswe rhoqo kwaye ngaphambi kokuba kuvele ithumba, wongeza ugxa ka-Hilakivi kunye nomfundi ophumeleleyo u-Xiyuan Zhang.
Iziphumo zolu phando zixhasa izifundo zokujonga ezibonisa ukuba abafazi abasebenzisa ngaphezulu kwe-10 mg ye-isoflavones imihla ngemihla ixesha elide banomngcipheko omncinci womhlaza webele xa kuthelekiswa nabasetyhini abatya ngaphantsi kwe-4 mg ye-isoflavones yonke imihla.
Ikomityi yobisi lwesoya (240 ml) sele iqulethe malunga ne-30 mg ye-isoflavones. Uninzi lwalo lubandakanya i-genistein. Incinci njengesithathu sekomityi ngosuku iya kwanela, okanye iqhekeza elincinci letofu, okanye inani elincinci leyogathi yesoya.
Ke ukuba ubuthanda iimveliso zesoya iminyaka, akufuneki uyeke ukuzitya ngenxa ye-soy hysteria jikelele okanye emva kokuxilongwa komhlaza webele. Ngokuchasene noko: Kunokwenzeka ukuba amajoni omzimba anokuthintela kuphela umhlaza okanye ajongane nokufa komhlaza okhoyo ngoncedo lwesoya.
Isoya ikhusela ijini yomhlaza wamabele iBRCA1
I-Soy kuthiwa ikwazi ukukhusela into ebizwa ngokuba yi-breast cancer gene BRCA1 ukuze ikwazi ukuqhubeka nokusebenza njenge-inhibitor yomhlaza webele. I-BRCA1 ibizwa ngokuba yijini yomhlaza webele, kodwa hayi kuba ihlala inyusa umngcipheko womhlaza wamabele. Endaweni yoko, wonke umntu obhinqileyo nayo yonke indoda inofuzo lwe-BRCA1. Kuphela kuxa umzila wemfuza ubonisa utshintsho oluthile oku kunokukhokelela kumngcipheko owongezelelekileyo womhlaza wamabele, ekubeni ukhuselo lomzimba kumhlaza wamabele luthi ke lube buthathaka kakhulu.
I-gene enempilo ye-BRCA1, ngakolunye uhlangothi, icinezela ukuphuhliswa komhlaza wesifuba - kunye ne-genistein, i-isoflavone efana ne-estrogen efumaneka kwiimbotyi zesoya, ibonakala ikhusela kwaye igcina lo msebenzi ophilileyo we-BRCA1 gene, abaphandi kwiYunivesithi yaseArizona Cancer Centre. ngoJuni 2017 ifumene iTucson kwiimvavanyo zokuqala ze-in-vitro. Iziphumo zapapashwa kwiphephancwadi Current Developments in Nutrition.
Ukusetyenziswa kwesoya kunokwenza unyango lomhlaza olungasebenziyo lusebenze kwakhona
Kwezinye iimeko, umhlaza okhoyo awusaphenduli kunyango oluqhelekileyo lomhlaza nge-tamoxifen. Nangona kunjalo, ukuba ijini ye-BRCA1 ekhubazekileyo ivuselelwe ngoncedo lwe-soy bean genistein, i-tamoxifen inokusebenza kuphela njengoko bekulindelekile kwakhona. Ukusetyenziswa rhoqo kwesoya kunokuba nefuthe elihle kakhulu kunyango lomhlaza. Abaphandi abavela eTucson ngoku balungiselela iimvavanyo ezongezelelweyo kunye nezifundo zeklinikhi ukuvavanya indlela efunyenweyo yokusebenza ebantwini.
