Allison Turner
Iqembu labacwaningi bamazwe ngamazwe lingase lizuze impumelelo ekwelapheni i-multiple sclerosis. Emfanekisweni wezilwane, ukusetshenziswa kwezinto zezitshalo (ama-cyclotides) kulethe impumelelo yokuqala, enkulu. Emuva.
Ngokuzayo, isifo esizimelayo sokuzivikela ezifweni i-multiple sclerosis sizolapheka. Abacwaningi baseMEDUni Vienna kanye nozakwabo bocwaningo lwamazwe ngamazwe (Australia, Germany, naseSweden) bayaqiniseka ngalokhu.
Kuze kube manje, i-multiple sclerosis ayikwazi ukwelapheka, kodwa ingelapheka. Lesi sifo singelashwa ngemithi efana ne-cortisone - kodwa ngemiphumela engemihle. Ithimba labacwaningi bamazwe ngamazwe eliholwa umqondisi wocwaningo uChristian Gruber manje selithathe elinye igxathu ekulweni ne-MS. Bacabanga ukuthi ama-polypeptides ezitshalo (ama-cyclotides) azolapha i-MS.
Isifo esicashile se-multiple sclerosis
Amasosha omzimba kufanele avikele umzimba wawo kubahlaseli noma alwe nokuvuvukala. Akunjalo nge-multiple sclerosis (MS) - isifo esizimele sohlelo lwezinzwa oluphakathi. Umzimba uqondisa izivikelo zawo kuwo ngokwawo. Ngenxa yalokho, izingqimba ezivikelayo zemicu yayo yezinzwa (i-myelin noma ungqimba lomnkantsha) ebuchosheni nasemgogodleni ziyavutha. Ukudluliswa kwe-Stimulus kwenziwa kube nzima kakhulu noma kucishe kungenzeki uma kuhlakazwe ngokuphelele.
Ezigulini ze-MS, lokhu kuzibonakalisa ekukhubazekeni kwemisipha yobuso, ukuphazamiseka kokukhuluma, kodwa nokungakwazi ukuzibamba komchamo. Lesi sifo siqhubeka ngezigaba, ezibonakala ekuqubukeni okusha noma okuphindelelayo kwezimpawu ezaziwayo.
I-Vitamin D kanye ne-multiple sclerosis
Izindlela zokuvuvukala nezimbangela kuze kube manje ziye zacaciswa kancane. Ukushoda kwe-vitamin D kusolwa, isibonelo. Izidakamizwa ezifana ne-cortisone zivimbela ukuvuvukala futhi zingasetshenziswa ukwelapha ukuqubuka okukhulu. Izimpawu ziyehla ngemva kwesikhashana. Ububi obukhulu ukuthi zingasetshenziswa kuphela ngomjovo futhi zibe nemiphumela emibi kakhulu.
Ngotamatisi empumelelweni
Ama-Cyclotides ama-peptides (amaprotheni amancane) atholakala ezitshalweni ezihlukahlukene ezifana nama-nightshades (utamatisi), utshani nezitshalo zekhofi futhi angamisa izinqubo zokuvuvukala kumasosha omzimba. Abacwaningi bathola ukuthi bacindezela ukukhululwa kwento eyi-messenger interleukin-2 futhi bavimbele ukuhlukana kwamangqamuzana ama-T cell (amangqamuzana “abulalayo” noma “omsizi”).
Ososayensi base-MedUni Vienna, kanye nozakwabo bocwaningo lwamazwe ngamazwe, basebenzisa ulwazi ngezinto zezitshalo futhi benza ucwaningo lwegundane. "Esibonelo sezilwane ze-MS, ukuvela kwezimpawu kwancipha kakhulu ngokuphathwa ngomlomo kwama-cyclotide," kusho umholi weqembu locwaningo uChristian Gruber.
Bakwazi ukukhombisa ukuthi ukuthatha ngomlomo okukodwa kwe-peptide yesitshalo kungamisa i-MS kusenesikhathi. Isikhathi phakathi kokuhlaselwa saba side futhi i-foci yokuvuvukala iyancipha. Izilwane azizange zibonise imiphumela emibi.
Bashicilele imiphumela yocwaningo lwabo ku-PNAS (Proceedings of the National Academy of Science of the United States of America).
Ukutholwa kososayensi kunikeza ithemba ezigulini ze-MS
Abacwaningi bacabanga ukuthi imiphumela yocwaningo lwabo ingadluliselwa kubantu.
“Ngokushesha nje lapho ukusilela kwemizwa okusebenzayo kwenzeka futhi izinguquko zokuqala ezihlobene nesifo ohlelweni lwezinzwa olumaphakathi zibonakala ekuhlolweni kwe-MRI (Qaphela: Ukufanekisa Kwe-Magnetic Resonance), umuthi ungasetshenziswa njengendlela yokwelapha eyisisekelo. Ngakho-ke kungenzeka ukuthi isikhathi esiphakathi kokuqubuka komlilo sinwetshiwe noma kungavinjelwa ukuqubuka kwalesi sifo,” kusho ososayensi ngethemba.
Njengomphumela wocwaningo lwamagundane oluyimpumelelo, i-MedUni Vienna, ikanye neFreiburg University Hospital, yafaka izicelo zobunikazi besitshalo se-peptide emazweni amaningana futhi yasungula inkampani yeCyclone. Inhloso ukuthuthukisa isidakamizwa esisebenza ngomlomo esizokwenza iziguli ze-MS ziphile impilo "evamile". Ngokusho kwabacwaningi, isifundo somtholampilo sesigaba sokuqala sokuqala singaqala ngasekupheleni kuka-2018.
